Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
By J. Fahey, X. Haristoy, P. Dolan, T. Kensler, Isabelle Scholtus, K. Stephenson, P. Talalay, A. Lozniewski. Proceedings of the National Academy of Sciences of the United States of America, 2002
820 citations recorded by the source corpus.
Subfields: Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/5c1cd218fe5802ff16d7dadc75ff9daf29aac2c4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- A. Dinkova-Kostova
- Liam Baird
- Donna D. Zhang
- Q. Ma
- Melba C. Jaramillo
- J. Gershenzon
- B. Halkier
- T. Kensler
In Surgery
Citations in the corpus
- Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. (2011, background): “Sulforaphane has been extensively examined for its chemopreventive properties and is a potent activator of the Nrf2-Keap1 pathway leading to increased expression of carcinogen detoxifying enzymes (Dinkova-Kostova et al., 2007; Fahey et al., 2002).”
- The cytoprotective role of the Keap1–Nrf2 pathway (2011, background): “Another curious property of sulforaphane is its bactericidal activity against Helicobacter pylori infections, which are strongly associated with gastric cancer (Fahey et al. 2002).”
- Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. (2007, background): “pylori in the test tube and in tissue culture, including antibiotic resistant strains [125].”
- The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “In addition, Nrf2-deficient mice had a higher incidence of bladder tumors following exposure to N-nitrosobutyl(4-hydroxybutyl)amine (Fahey et al. 2002) as well as an increased incidence of skin tumors after exposure to 7,12-dimethylbenz(a)anthracene or 12-O-tetradecanoylphorbol-13-acetate, two poten”
- An important role of Nrf2-ARE pathway in the cellular defense mechanism. (2004, background): “Finally, Fahey and coworkers showed that an ARE inducer, sulforaphane, which is abundant in broccoli, is a potent bacteriostatic agent against Helicobacter pylori and blocks benzo[a]pyrene-evoked forestomach tumors in ICR mice suggesting the dual actions of sulforaphane may function synergistically ”
- Biology and biochemistry of glucosinolates. (2006, background): “Moreover, sulforaphane exhibits potential for treating Helicobacter pylori-caused gastritis and stomach cancer (48).”