The therapeutic potential of modulating the ceramide/sphingomyelin pathway.

By R. Kolesnick. 2002

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Mammalian Ceramide Synthases (2010, background): “SLs is ceramide, which has received wide attention over the past couple of decades because of its proposed role as an important intracellular signaling molecule involved in regulating differentiation, proliferation, and apoptosis (1, 2).”
Cannabinoids: potential anticancer agents (2003, background): “— a lipid second messenger that can induce apoptosis and cell-cycle arres”
Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. (2008, background): “Ceramidases, which can sometimes catalyze the reverse reaction to convert sphingosine back into ceramide, can be distinguished by their pH optima (22).”
Sphingosine-1-phosphate: an enigmatic signalling lipid (2003, background): “By contrast, its precursors — ceramide ( N -acyl sphingosine) and sphingosine — have generally been associated with growth arrest and cell deat”