Sphingosine-1-phosphate: an enigmatic signalling lipid

By Sarah Spiegel, S. Milstien. Nature reviews. Molecular cell biology, 2003

2,141 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6b3a1271a9b866bf91af0a4541db26cfbf0a70a7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. Futerman
2. Yusuf A. Hannun
3. LM Obeid
4. J. Cyster
5. Susan R. Schwab
6. Michael Maceyka
7. J. Chun
8. S. Milstien

In Molecular Biology

1. A. Futerman
2. Yusuf A. Hannun
3. LM Obeid
4. Sarah Spiegel
5. S. Milstien
6. Susan R. Schwab
7. J. Cyster
8. S. Summers

Citations in the corpus

• “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “Because the dynamic balance between the cellular levels of ceramide and S1P can determine cell fate, the enzymes that regulate this balance are potential targets for the development of new anticancer drugs that decrease S1P and/or increase ceramide (Spiegel and Milstien, 2003).”
• Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “S1P has a dual function as an intercellular signaling molecule and as an intracellular metabolic intermediate; all cells are thought to be able to generate S1P in the process of normal sphingolipid turnove”
• Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis (2010, background): “SPHINGOSINE 1-PHOSPHATE BIOLOGY AND ITS RELEVANCE TO THE PATHOLOGIC FEATURES OF MS Sphingolipids were first identified in ethanolic brain extracts in the 1870s and were named after the Greek mythological creature, the Sphinx, because of their enigmatic nature.(32) Sphingosine 1-phosphate represents ”
• Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (2022, background): “Sphingosine-1-phosphate receptor (S1PR)-related signaling pathways during neuroinflammation in ischemic stroke S1PRs form a group of G protein-coupled receptors abundant in microglia and are thought to regulate inflammatory responses in ischemic stroke.(308) In vitro studies have shown that the addi”
• Principles of bioactive lipid signalling: lessons from sphingolipids (2008, background): “An overwhelming amount of primary literature has established the participation of the SK1–S1P–S1PR axis in multiple signalling pathway”
• The Pleiotropic Actions of Adiponectin are Initiated via Receptor-Mediated Activation of Ceramidase Activity (2010, background): “, and ample evidence in the literature couples sphingosine and S1P with calcium influx and release from the endoplasmic reticulu”
• The complex life of simple sphingolipids (2004, background): “…the activation of pkh kinases in yeast; Friant et al, 2001), S1P (primarily through the endothelial differentiation gene (EDG)/S1P receptors; Spiegel & Milstien, 2003) and ceramide (through phosphatases and cathepsin D; Ruvolo, 2003), and such progress should allow the molecular…”
• Cell Biology of Cnidarian-Dinoflagellate Symbiosis (2012, background): “known to function in cell fate and immunity in animals (336).”