MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

By R. Garzon, Shujun Liu, M. Fabbri, Zhongfa Liu, Catherine E. A. Heaphy, E. Callegari, S. Schwind, Jiuxia Pang, Jianhua Yu, N. Muthusamy and 12 more. Blood, 2009

787 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5bb5ae32f50bc978417b513c4b8ee759d7b66581

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Citations in the corpus

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. (2016, neutral): “ESR1 hypomethylation has been reported in relation to induced microRNA expression (synthetic miR-29b oligonucleotides) in acute myeloid leukemia cells.(88) To evaluate possible functional gene expression effects of methylation at the CpGs that we found to be significantly related to maternal smoking”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, positive): “As miRNAs, in particular the miR-29 family, have been shown to downregulate DNA methyltransferases ( DNMT1 , DNMT3a and DNMT3b ) and to induce global DNA hypomethylation and tumour-suppressor gene re-expressio”
microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer (2011, background): “miR-29 can modulate the expression of DNMT-1 and 3B in leukemia and lung cancer cells (Fabbri et al., 2007; Garzon et al., 2009).”
Epigenetic modifications and human disease (2010, background): “The miR-29 family is known to directly target and downregulate DNMT3A and DNMT3B, and indirectly target DNMT1 (ref”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Intriguingly, downregulation of the miRNA-29 family has also been linked to overexpression of DNA methyltransferase”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “In addition, miR-29b has been shown to repress specific DNA methyltransferases leading to global DNA hypomethylation and re-expression of tumour suppressor genes, thus implicating this miRNA as a tumour suppresso”
MicroRNAs in development and disease. (2011, background): “Ectopic expression of miR-29 also induces upregulation of the cell cycle inhibitors p15 and ESR1 through demethylation of their promoters via directly targeting the methyltransferases DNMT3A and DNMT3B and indirectly DNMT1 (200).”
MicroRNAs in cancer: small molecules with a huge impact. (2009, background): “To complicate the scenario connecting microRNAs and epigenetics, microRNAs themselves can regulate the expression of components of the epigenetic machinery, creating a highly controlled feedback mechanism: the miR-29 family directly targets the de novo DNA methyltransferases DNMT-3A and -3B, althoug”
Causes and consequences of microRNA dysregulation in cancer (2009, background): “has shown that miR-29s target not only DNMT3A and DNMT3B but also, indirectly, the DNMT1 maintenance DNM”
microRNAs in cancer (2013, background): “Additional information on the role of miRNAs in tumorigenesis has been acquired through analysis of phenotype via conditional deletion of Dicer, which mimics the general knockdown of miRNAs in tumors. miR-155 In 2006, our laboratory described the first mouse model of miRNA overexpression, the Eμ-miR”
Epigenetics and Colorectal Cancer (2011, background): “Emerging data show that, in humans, miRNAs can induce aberrant DNA methylation by directly targeting DNA methyltransferases”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “And mir-29b directly represses expression of DNMT3A and DNMT3B, resulting in DNA hypomethylation in acute myeloid leukemia (Garzon et al., 2009).”