Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease.

By S. Klein, Luigi Fontana, V. Young, Andrew R Coggan, C. Kilo, Bruce W. Patterson, B. Mohammed. New England Journal of Medicine, 2004

818 citations recorded by the source corpus.

Subfields: Dermatology, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/5b9ce3f49c91766dd106c287b15207c55bd07486

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. J. Kirkland
2. J. V. van Deursen
3. T. Tchkonia

In Pharmacology

1. Joseph A. Hill
2. S. Malnick
3. H. Knobler

In Surgery

1. P. Scherer
2. S. Malnick
3. C. R. Kahn
4. L. Bacon
5. H. Knobler
6. L. Aphramor
7. A. Chait
8. Laura J. den Hartigh

Citations in the corpus

• Fat Tissue, Aging, and Cellular Senescence (2010, background): “Removing large amounts of subcutaneous fat from humans does not improve insulin sensitivity (Klein et al., 2004).”
• Weight Science: Evaluating the Evidence for a Paradigm Shift (2011, background): “5 kgs but saw no improvements in obesity-associated metabolic abnormalities, including blood pressure, triglycerides, cholesterol, or insulin sensitivity [98].”
• Why Does Obesity Cause Diabetes? (2022, background): “For example, the removal of large amounts of subcutaneous abdominal adipose tissue (10 kg of adipose tissue which was equal to a 12% body weight loss and a decrease in 20% of total body fat mass) by using liposuction does not improve adipose tissue, liver or skeletal muscle insulin sensitivity or pl”
• Beneficial effects of subcutaneous fat transplantation on metabolism. (2008, background): “…adverse metabolic effects, omentectomy, i.e., removal of visceral fat, results in decreased insulin and glucose levels in humans (Thorne et al., 2002), whereas removal of subcutaneous fat by liposuction does not result in improvement in any aspect of the metabolic syndrome (Klein et al., 2004).”
• Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. (2019, background): “The infusion of [U-13C]glucose was stopped during insulin infusion because of the expected decrease in hepatic glucose production (55).”
• Cardiac remodeling in obesity. (2008, background): “The removal of subcutaneous fat by liposuction does not appear to produce beneficial metabolic changes (182).”
• Disordered lipid metabolism and the pathogenesis of insulin resistance. (2007, neutral): “The notion of energy intake exceeding adipose tissue storage capacity is further supported by the finding that weight loss induced by large-scale liposuction fails to improve the metabolic status of obese humans (54), in effect this procedure simply reduces adipose tissue storage capacity in the fac”
• Metabolic flexibility in health and disease (2017, neutral): “Reducing fat mass via surgical removal (liposuction) of WAT does not produce metabolically beneficial results (Klein et al., 2004), pointing toward the need for a calorierestriction-induced and/or an exercise-induced remodeling of WAT in order to achieve metabolic improvements within the adipose tis”