Drug Seeking Becomes Compulsive After Prolonged Cocaine Self-Administration

By L. Vanderschuren, Barry J. Everitt. Science, 2004

734 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/5b8be194c957abc8e7b3f7aea20c0e4765ea1ed3

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Citations in the corpus

Reward Mechanisms in Obesity: New Insights and Future Directions (2011, background): “Indeed, rats with a history of extensive cocaine consumption display intake that is resistant to disruption by an aversive conditioned stimulus (CS) predicting negative outcome (i.e., a cue light that predicts delivery of aversive footshock) (Belin et al., 2008; Vanderschuren and Everitt, 2004).”
Addiction-like reward dysfunction and compulsive eating in obese rats: Role for dopamine D2 receptors (2010, positive): “Together, our data support the idea that compulsive-like eating behavior can emerge in extended-access rats in a manner analogous to the compulsive cocaine-taking seen in rats with a history of extended access to the dru”
Cognitive Bias Modification and Cognitive Control Training in Addiction and Related Psychopathology (2013, background): “…the result that after prolonged drug use, the addictive behavior can persist despite (lack of) reward or even punishment and can thus develop from an impulsive outcome-focused behavior to compulsive habitual behavior (Everitt et al., 2008; Everitt & Robbins, 2005; Vanderschuren & Everitt, 2004).”
The incentive sensitization theory of addiction: some current issues (2008, background): “…2004; Ferrario et al. 2005), increased motivation to take drug (Paterson & Markou 2003), continued drug seeking in the face of adverse consequences (Vanderschuren & Everitt 2004; Pelloux et al. 2007) and a greater propensity for reinstatement (Ahmed & Koob 1998; Ferrario et al. 2005; Knackstedt &…”
Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction (2008, background): “(Deroche-Gamonet et al. 2004; Vanderschuren & Everitt 2004; Pelloux et al. 2007).”
Neural mechanisms of addiction: the role of reward-related learning and memory. (2006, background): “Because we know the proximate cause of addiction, the drugs themselves, it has been possible to model some aspects of addiction in animals (Deroche-Gamonet et al. 2004, Vanderschuren & Everitt 2004) more effectively than it has been possible to model most psychiatric disorders.”
Neural systems of reinforcement for drug addiction: from actions to habits to compulsion (2005, background): “Compulsive drug seeking and drug taking are the hallmarks of the definitions of drug addiction (or 'dependence' in the Diagnostic and Statistical Manual IV ), which is becoming increasingly acknowledged by neuroscientists modeling this behavio”
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. (2008, background): “The power of ‘‘craving’’ is evidenced by results showing that animals will sometimes face adverse consequences to obtain a substance of abuse such as cocaine or alcohol (Deroche-Gamonet et al., 2004; Dickinson et al., 2002; Vanderschuren and Everitt, 2004).”
Addiction and the brain antireward system. (2008, background): “…drug seeking in the presence of an aversive conditioned stimulus or punishment, which has face validity for the DSM-IV criteria of “continued substance use despite knowledge of having a persistent physical or psychological problem” (Deroche-Gamonet et al. 2004, Vanderschuren & Everitt 2004).”
Neurocircuitry of Addiction (2009, background): “Changes in the reinforcing and incentive effects of the drug have been observed following extended access and induction of dependence and include increased progressive-ratio responding (Koob, 2009a), increased drug-induced reinstatement after extinction, decreased latency to goal time in a runway mo”