MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function.

By D. Humphreys, B. Westman, David I. K. Martin, T. Preiss. Proceedings of the National Academy of Sciences of the United States of America, 2005

710 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5b8798e6246488ef1f8c750e7e4b0042a2880e35

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In Cardiology and Cardiovascular Medicine

1. Nahum Sonenberg
2. W. Filipowicz
3. T. Nilsen

In Molecular Biology

1. T. Nilsen
2. R. Parker
3. W. Filipowicz
4. Elisa Izaurralde
5. Nahum Sonenberg
6. Gregory J. Hannon
7. Tobias Doerks
8. I. Behm-Ansmant

Citations in the corpus

• Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “This is based on the observations that transfected capped, unadenylated mRNAs can be subject to miRNA-based repression (Humphreys et al. 2005; Pillai et al. 2005).”
• Origins and Mechanisms of miRNAs and siRNAs (2009, background): “On the basis of these criteria, some studies have found evidence for miRISC-repressed initiation (Humphreys et al., 2005; Pillai et al., 2005; Kiriakidou et al., 2007; Mathonnet et al., 2007; Wakiyama et al., 2007; Ding and Grosshans, 2009).”
• Argonaute proteins: key players in RNA silencing (2008, background): “The studies supporting this mechanism showed that most miRNA-mediated gene regulation requires the presence of the canonical cap and poly(A) tail on the targeted RN”
• mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “Recent studies have shown that miRNAs silence gene expression by inhibiting translation initiation at an early stage involving the cap structure, as mRNAs translated via cap-independent mechanisms escape miRNA-mediated silencing (Humphreys et al. 2005; Pillai et al. 2005).”
• Getting to the root of miRNA-mediated gene silencing. (2008, background): “…through cap-independent mechanisms (that is, through an IRES) were refractory to repression by miRNAs, further supporting the notion that miRNAs inhibit cap- r Inc. dependent translation initiation (Humphreys et al., 2005; Pillai et al., 2005; Mathonnet et al., 2007; Wakiyama et al., 2007).”
• miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “MicroRNAs (miRNA) are known to regulate gene expression by binding to the 30 UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression (Humphreys et al, 2005; Pillai et al, 2005; Petersen et al, 2006; Chendrimada et al, 2007).”
• MicroRNAs in development and disease. (2011, background): “A second mode of function employed by miRNAs is inhibition of translation initiation, which requires both the cap (253, 487, 608) and poly(A) tail structures (253).”