A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition.

By A. Malhotra, Lisa Kestler, C. Mazzanti, J. Bates, Terry E. Goldberg, David Goldman. American Journal of Psychiatry, 2002

631 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/5b0321704bc5751b79bf50533826fc5a14be5191

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Wayne C. Drevets
2. J. Volavka
3. David Goldman
4. Herbert M. Lachman
5. Robert M. Bilder
6. Anthony A. Grace
7. Husseini K. Manji
8. G. Oroszi

In Cognitive Neuroscience

1. Husseini K. Manji
2. Dennis S. Charney
3. G. Hasler
4. Ulman E. R. Lindenberger
5. Anthony A. Grace
6. Wayne C. Drevets
7. J. Volavka
8. Lars Nyberg

In Experimental and Cognitive Psychology

1. Ulman E. R. Lindenberger
2. Lars Nyberg
3. Anthony A. Grace
4. Lars Bäckman
5. G. Hasler
6. Dennis S. Charney
7. Timothy Salthouse
8. Diego A. Pizzagalli

Citations in the corpus

• The genetics of addictions: uncovering the genes (2005, methodology): “Consistent with the role of dopamine in the tuning of frontal cortical function, the Val158 allele and Val158 haplotypes have replicably been linked to frontal lobe function, as assessed by measures such as the WISCONSIN CARD-SORT TEST and the N-BACK TEST”
• The correlative triad among aging, dopamine, and cognition: current status and future prospects. (2006, background): “…et al. / Neuroscience and Biobehavioral Reviews 30 (2006) 791–807 795 perseverative errors in the Wisconsin Card Sorting Test; Egan et al., 2001; Joober et al., 2002; Malhotra et al., 2002; Mattay et al., 2003) as well as in tasks assessing processing speed and attention (Bilder et al., 2002).”
• Candidate mechanisms for chemotherapy-induced cognitive changes (2007, background): “COMT is an important modulator of the amount of dopamine in the frontal cortex, accounting for ∼60% of the metabolic degradation of dopamin”
• Discovering Endophenotypes for Major Depression (2004, background): “In healthy humans and schizophrenic patients, a functional polymorphism of the COMT gene appeared to explain some of the individual variance in working memory performance (Egan et al, 2001; Malhotra et al, 2002).”
• The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, result): “70 The results in schizophrenia have been mixed, with a recent meta-analysis 71 reporting no overall evidence for association with the valine allele.”
• The Catechol-O-Methyltransferase Polymorphism: Relations to the Tonic–Phasic Dopamine Hypothesis and Neuropsychiatric Phenotypes (2004, background): “…far have examined associations of COMT genotype with various cognitive abilities in healthy individuals and/or people with schizophrenia (Bilder et al, 2002; Diamond et al, 2004; Egan et al, 2001; Goldberg et al, 2003; Joober et al, 2002; Malhotra et al, 2002; Nolan et al, 2004; Tsai et al, 2003).”