The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception.

By B. Bufe, P. Breslin, C. Kuhn, D. Reed, Christopher D. Tharp, J. P. Slack, U. Kim, D. Drayna, W. Meyerhof. Current Biology, 2005

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Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer (2009, background): “Heterologous expression experiments have successfully enabled the identification of cognate bitter compounds for 13 out of the known 25 hTAS2Rs (Behrens et al. 2004; Brockhoff et al. 2007; Bufe et al. 2005; Bufe et al. 2002; Chandrashekar et al. 2000; Dotson et al. 2008; Kuhn et al. 2004; Maehashi e”
The molecular receptive ranges of human TAS2R bitter taste receptors. (2010, background): “Collectively, the data suggest that the promiscuity of TAS2Rs appears to be greater than anticipated (Bufe et al. 2002, 2005).”
Common Sense about Taste: From Mammals to Insects (2009, background): “On the one hand, knockout (Mueller et al., 2005) or genetic alterations (Kim et al., 2003; Bufe et al., 2005) of specific T2Rs leads to changes in bitter taste sensitivity and selectivity.”
Chemical ecology in coupled human and natural systems: people, manioc, multitrophic interactions and global change (2010, background): “Individuals with lower sensitivity to allelochemicals that have positive effects might ingest more of them and thereby obtain greater benefits (Bufe et al. 2005; Soranzo et al. 2005).”