Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
By B. Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L. Carstens, Xiaofeng Zheng, Chia-Chin Wu, T. Simpson, Hanane Laklai, H. Sugimoto, Christoph Kahlert, Sergey Novitskiy and 11 more. Cancer Cell, 2015
1,337 citations recorded by the source corpus.
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Citations in the corpus
- Carcinoma-associated fibroblasts: orchestrating the composition of malignancy (2016, background): “Indeed, recent studies have shown that targeting CAFs may result in protumorigenic effects depending on the target and the tissue context (Ozdemir et al. 2014; Koliaraki et al. 2015; Wagner 2016).”
- Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. (2019, background): “For instance, although ablation of cells that express the myofibroblast marker alpha smooth muscle actin (αSMA) in a PDAC mouse model reduced desmoplasia, the resulting tumors were highly undifferentiated, intratumoral blood vessels were further diminished in number with hypoxic necrosis evident, an”
- Integrin-mediated mechanotransduction (2016, background): “…normal cells such as chondrocytes are armed with a bulky mucin-enriched glycocalyx, which induces a cellular perception of high ECM stiffness even on soft substrate and facilitates cancer cell survival and proliferation in a FAK- and phosphoinositide 3-kinase–dependent manner (Paszek et al., 2014).”
- Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Cellax (Docetaxelconjugate nanoparticles) α-SMA-targeted nanoparticles None Enhances anti-stromal effect and inhibits tumor metastasis and angiogenesis PDAC and breast cancer Preclinical [309, 310]”
- New horizons in tumor microenvironment biology: challenges and opportunities (2015, background): “The naive stroma is a critical compartment in maintaining physiological homeostasis of normal tissue, and recent studies strengthened the concept that some stromal components have anticancer activities by regulating immunosuppression and restraining carcinogenesis, which is particularly the case of ”
- The extracellular matrix modulates the hallmarks of cancer (2014, positive): “A recent study abrogating stromal fibroblasts from pancreatic tumors suggests that the influences of this cell population on ECM composition and mechanical stiffening are inhibitory to tumor progression [134].”
- Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy (2019, background): “However, targeting α-SMA might increase the immunosuppressive CD3Foxp3 Tregs infiltrate in the TME, which ultimately led to aggressive tumor development [126].”
- Inflammation and Cancer: Triggers, Mechanisms and Consequences (2019, background): “On the other hand, under different circumstances, CAFs or inflammatory signaling in CAFs may also be tumor suppressive (Ozdemir et al., 2015; Pallangyo et al., 2015).”