Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

By Philippe Gascard, Thea D. Tlsty. Genes & Development, 2016

677 citations recorded by the source corpus.

In this review, Gascard and Tlsty focus on novel insights into the contributions of carcinoma-associated fibroblasts (CAFs) to disease progression. They also discuss the generation of CAFs and recent therapeutic approaches aimed at blunting or reverting detrimental protumorigenic phenotypes associated with CAFs.

Subfields: Oncology, Oral Surgery

View Paper: https://www.semanticscholar.org/paper/2a9d8c4d6e3990c931b109f892dba389d93530de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Alexey I. Nesvizhskii
2. Andy T. Kong
3. David J. Clark
4. Dmitry Avtonomov
5. S. Dhanasekaran
6. C. Kratochwil
7. C. Ricketts
8. F. Petralia

Citations in the corpus

• The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses (2020, background): “CAFs comprise up to 80% of the tumor mass in pancreatic and breast cancers that are both connected to high level of myeloid cell infiltration (159).”
• Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2019, background): “Together, these associated pathways are representative of TME-tumor crosstalk, with PDGF signaling driving fibroblast recruitment and activation, and CAFs subsequently inducing an EMT-phenotype in tumors (Gascard and Tlsty, 2016; Seppä et al., 1982).”
• Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer (2017, neutral): “…play a critical role in cancer initiation, growth, invasion, metastasis, and therapeutic resistance through the production of growth factors, cytokines, chemokines, catabolites, extracellular matrix proteins, and EVs, which modulate the behavior of cancers, including their metabolism (15 – 18).”
• Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein (2018, background): “210443 Cancer-associated fibroblasts modulate the microenvironment of malignant tumors by secreting factors that regulate both malignant cells and nonmalignant cells such as immune and endothelial cells (1).”
• In search of definitions: Cancer‐associated fibroblasts and their markers (2019, background): “Two markers, Microfibril Associated Protein 5 (MFAP5) and Collagen Type XI Alpha I Chain (COL11A1), have also been suggested to be highly specific CAF-markers.(29,55) Their usage is currently still limited amongst the academic community, and further characterization of these markers and their behavi”