Heat shock factors: integrators of cell stress, development and lifespan

By M. Åkerfelt, Richard I. Morimoto, Lea Sistonen. Nature reviews. Molecular cell biology, 2010

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Heat shock factors (HSFs) are essential for all organisms to survive exposures to acute stress. They are best known as inducible transcriptional regulators of genes encoding molecular chaperones and other stress proteins. Four members of the HSF family are also important for normal development and lifespan-enhancing pathways, and the repertoire of HSF targets has thus expanded well beyond the heat shock genes. These unexpected observations have uncovered complex layers of post-translational regulation of HSFs that integrate the metabolic state of the cell with stress biology, and in doing so control fundamental aspects of the health of the proteome and ageing.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e8cc4c25b298bde9c5b5203ee9a0c7b9f4d1b92a

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Citations in the corpus

The heat shock response: life on the verge of death. (2010, background): “Hsf1 regulation is more complex than that of s32, as phosphorylation, other posttranslational modifications, and oligomerization regulate Hsf1 activity (Akerfelt et al., 2010; Prahlad and Morimoto, 2009).”
Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “2013), HSF and NRF2 (Akerfelt et al., 2010; Martín-Montalvo et al., 2011).”
Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets (2018, background): “…of genes enriched for oxidative stress and senescence pathways (Figs 2F and EV2A), with the top weights corresponding to heat-shock proteins (HSPs; Fig EV2B and C), genes that are essential for protein folding and are up-regulated upon stress conditions (Srivastava, 2002; A˚kerfelt et al , 2010).”
CENTRAL AND PERIPHERAL CIRCADIAN CLOCKS IN MAMMALS (2012, background): “Because HSF1 is influenced by a wide range of signaling pathways in the cell (Akerfelt et al. 2010), temperature and HSF1 may form a final common pathway for the integration of resetting signals in peripheral clocks.”
Hydrogen peroxide sensing, signaling and regulation of transcription factors (2014, background): “The mammalian heat shock factor (HSF) family has four members HSF, HSF2, HSF3 and HSF4 but HSF1 is the key stress-responsive regulator of the heat shock response [82].”
Pathways of cellular proteostasis in aging and disease (2018, background): “Because of the broad range of components sequestered by protein aggregates, enhancement of the endogenous stress-response pathways themselves has been particularly fruitful in extending lifespan and proteostatic health (Sittler et al., 2001; Mu et al., 2008; Akerfelt et al., 2010; Kumsta et al., 201”
The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae (2012, background): “Indeed, microarray analysis using conditional and knockout mutants, respectively, of the HSF1, MSN2, and MSN4 genes suggests that these three factors are responsible for the bulk if not the entirety of the HSR (Figure 1).”
Exosomes in Cancer Development, Metastasis and Drug Resistance: A Comprehensive Review (2013, positive): “Hsps are a class of functionally related proteins that are activated in response to high temperature and other stresses [75, 76].”
The plant heat stress transcription factor (Hsf) family: structure, function and evolution. (2012, background): “Model of the human Hsf1 activity cycle (according to Akerfelt et al. [31]; modified).”