Endothelial Regulation of Vasomotion in ApoE-Deficient Mice: Implications for Interactions Between Peroxynitrite and Tetrahydrobiopterin

By J. Laursen, Mark J. Somers, S. Kurz, Louise A. McCann, A. Warnholtz, B. Freeman, M. Tarpey, T. Fukai, D. Harrison. Circulation, 2001

767 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/596abfd4cfa2fb16c89fb93804487c41c54acd36

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Rhian M. Touyz
2. S. Dikalov
3. U. Förstermann
4. A. Shah
5. T. Fukai
6. Carmine Zoccali
7. E. Schiffrin

In Immunology

1. Rhian M. Touyz
2. A. Shah
3. S. Milstien
4. T. Fukai
5. Jian-Mei Li
6. U. Förstermann
7. T. Paravicini
8. S. Dikalov

In Physiology

1. Rhian M. Touyz
2. U. Förstermann
3. S. Dikalov
4. A. Shah
5. G. King
6. S. Milstien
7. T. Fukai
8. K. Sugamura

Citations in the corpus

• Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. (2018, background): “In ROS-mediated endothelial dysfunction, BH4 is oxidized to BH2 that cannot function as a cofactor of eNOS, thus leading to eNOS uncoupling [59].”
• NADPH Oxidases in Cardiovascular Health and Disease (2006, unknown): “Rac-GTP has also been reported to be capable of initiating signaling pathways leading to translocation of cytosolic oxidase subunits in COS-7 cells (278, 279, 295).”
• Reactive Oxygen Species in Cardiovascular Disease (2011, background): “Cholesterol-fed animals also exhibit eNOS uncoupling that is linked to the amount of BH4 in vascular tissues [106].”
• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “Likewise, peroxynitrite (a product of the reaction between NO and O2 ) may also oxidize BH4 and represent another pathogenic cause of eNOS uncoupling (91).”
• Chemistry and Biology of Pteridines and Folates (2002, methodology): “However, structural similarities exist with the regulatory domains of allosterically regulated enzymes phosphoglycerate dehydrogenase (involved in serine biosynthesis; Ser is the allosteric inhibitor) (15); threonine deaminase (involved in branched chain amino acid biosynthesis; lIe and Val are the ”
• Reactive Oxygen Species in Inflammation and Tissue Injury (2014, unknown): “The reduced bioavailability of BH4 has been reported to be due to oxidation by peroxynitrite, resulting in the formation of inactive BH2 (237).”
• Nitric oxide synthases: regulation and function. (2012, background): “…via the flavins FAD and FMN to the haem, where the substrate L -arginine is oxidized to L -citrulline and NO. 99 The reaction product of NO and O 2 2 105,106 and BH 4 levels have been found decreased in many models of cardiovascular disease 107–109,101 and in patients with endothelial dysfunction.”