Reactive Oxygen Species in Cardiovascular Disease
By K. Sugamura, J. Keaney. Free Radical Biology & Medicine, 2011
758 citations recorded by the source corpus.
Based on the ‘free-radical theory’ of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that ROS and oxidative stress are important features of cardiovascular diseases including atherosclerosis, hypertension, and congestive heart failure. However, blanket strategies with antioxidants to ameliorate cardiovascular disease have not generally yielded favorable results. However, our understanding or reactive oxygen species has evolved to the point that we now realize these species have important roles in physiology as well as pathophysiology. Thus, it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease. Indeed, there are several sources of reactive oxygen species that are known to be active in the cardiovascular system. This review will address our understanding of reactive oxygen species sources in cardiovascular disease and both animal and human data defining how reactive oxygen species contribute to physiology and pathology.
Subfields: Biochemistry, Nutrition and Dietetics, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/b11e230efa552347719fa756486d47edbfbc950a
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Citations in the corpus
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, background): “One potential reason for this is that oxidative stress can be triggered by downstream metabolites of TNF signaling, such as arachidonic acid, and oxidative stress is strongly implicated in cardiovascular endothelium health [272].”
- Reviews on Mechanisms of In Vitro Antioxidant Activity of Polysaccharides (2015, background): “On the other hand, many diseases, such as asthma, chronic obstructive pulmonary disease, inflammation, diabetes, myocardial infarction, and cardiovascular diseases, are reported to associate with oxidative stress [19–23].”