Spliceosomal UsnRNP biogenesis, structure and function.

By C. Will, Reinhard Lührmann. Current Opinion in Cell Biology, 2001

731 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5944055fae8a02543dcc3d380a305af137c1efa1

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Citations in the corpus

MicroRNA maturation: stepwise processing and subcellular localization (2002, background): “Nucleocytoplasmic transport (especially export) is critical in the expression and functions of RNAs (Wolin and Matera, 1999; Warner, 2001; Will and Luhrmann, 2001; Dreyfuss et al., 2002; Reed and Hurt, 2002).”
Interaction of the Vp3 Nuclear Localization Signal with the Importin α2/β Heterodimer Directs Nuclear Entry of Infecting Simian Virus 40 (2002, methodology): “(iii) Finally, two PCR fragments, one encoding Vp3(3-96) and the other encoding Vp3(96-164), were ligated through the non-”
Pre-mRNA splicing and human disease. (2003, background): “Once in the nucleus, snRNP-specific proteins are added to the core snRNPs to form active snRNPs (Will and Luhrmann 2001).”
Comprehensive proteomic analysis of the human spliceosome (2002, background): “Much has been learned about the protein components of the spliceosome from analysis of individual purified small nuclear ribonucleoprotein”
SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. (2008, positive): “snRNPs are major components of the spliceosome, the machinery that carries out pre-mRNA splicing (Nilsen, 2003; Will and Luhrmann, 2001).”
Listening to silence and understanding nonsense: exonic mutations that affect splicing (2002, background): “To generate correct, mature mRNAs, the exons must be identified and joined together precisely and efficiently, in a process that requires the coordinated action of five small nuclear (sn)RNAs (U1, U2 and U4–U6) and more than 60 polypeptide”
Comprehensive splice-site analysis using comparative genomics (2006, background): “The spliceosome is a large and dynamic complex assembled from RNA and protein components, including four small nuclear RNAs (snRNAs) and associated proteins that make up the small nuclear ribonucleoprotein particles (snRNPs) (4).”
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. (2005, background): “The methods used to detect U snRNAs with anti-TMG parallel the procedures described below for immunocytochemical detection of splicing proteins (see below).”