Olfactory representations by Drosophila mushroom body neurons.

By Glenn C. Turner, Maxim Bazhenov, Gilles Laurent. 2008

424 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Ecology, Evolution, Behavior and Systematics, Sensory Systems

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Considerable evidence has now accumulated that the mushroom body employs ultrasparse coding, as studies using a variety of methods, including whole-cell recordings, tetrode recordings, and calcium imaging, all found that only around 5-10% of Kenyon cells were active upon odour presentation (Figure 3”
Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “…not stereotyped (Figure 1A) (Murthy et al., 2008; Caron et al., 2013); that is, individual flies show distinct wiring patterns between projection neurons and KCs. Sparse activity of the KCs represents the identity of odors (Laurent and Naraghi, 1994; Perez-Orive et al., 2002; Turner et al., 2008).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “Odors activate sparse subpopulations of KCs distributed across the MB without spatial preference (Turner et al., 2008; Honegger et al., 2011; Campbell et al., 2013).”
Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning (2019, background): “In the mushroom body, odor identity is encoded by the activity of sparse ensembles of Kenyon cells (KCs) (Campbell et al., 2013; Turner et al., 2008) whose parallel axons bundle together to form output lobes.”
System-like consolidation of olfactory memories in Drosophila (2013, background): “…for retrieval is independent of odor selection Due to previous studies showing that odors are sparsely represented in the MBNs (Wang et al., 2003; Turner et al., 2008), with different odors perhaps represented unequally by the three subtypes of MBNs, there was the possibility that the memory…”
Synaptic organization in the adult Drosophila mushroom body calyx (2009, background): “Thus, for the estimated 1,115 boutons in the calyx (Turner et al., 2008), there would be a total of roughly 55,750 synapses.”
Are mushroom bodies cerebellum-like structures? (2011, background): “mushroom bodies in olfactory processing (Perez-Orive et al., 2002; Szyszka et al., 2005; Ito et al., 2008; Turner et al., 2008), where Kenyon cells have been proposed to transform olfactory inputs into a sparse codeperhaps as aprerequisite for encodingodorant identity for memory storage (Laurent, 20”
A connectome of a learning and memory center in the adult Drosophila brain (2017, background): “Thus, only a small subset of KCs respond to a given sensory stimulus (Perez-Orive et al., 2002; Turner et al., 2008; Honegger et al., 2011; Murthy et al., 2008).”
Shared mushroom body circuits underlie visual and olfactory memories in Drosophila (2014, background): “The specific contribution of αʹ/βʹ neurons to olfactory learning is consistent with the preferential representation of olfactory inputs to these neurons (Turner et al., 2008).”
Induction of aversive learning through thermogenetic activation of Kenyon cell ensembles in Drosophila (2014, background): “%) matches the reported number of Kenyon cells that are activated by odors (Turner et al., 2008; Honegger et al., 2011) and apparently reflects a range of sparseness that is optimized not only for information storage (coding), but also for memory readout (decoding).”
Functional analysis of a higher olfactory center, the lateral horn (2012, background): “In sharp contrast to the sparse spiking observed in KCs, which are targets of the PNs in the MB (Perez-Orive et al., 2002; Stopfer et al., 2003; Ito et al., 2008; Turner et al., 2008; Honegger et al., 2011), LHNs typically fired spontaneously and showed strong responses to odors (Fig.”
Cell Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression (2016, neutral): “The ~2500 KCs in each brain hemisphere receive inputs from olfactory projection neurons, encode odors both sparsely and specifically (Murthy et al., 2008; Turner et al., 2008), and send their outputs into the MB lobes.”
Testing odor response stereotypy in the Drosophila mushroom body. (2008, neutral): “…individuals. uron 59, 1009–1023, September 25, 2008 ª2008 Elsevier Inc. 1017 (1) the diversity of mKC types generated from five mPN types best matched the recorded KC diversity (Figure 5D), and (2) the net convergence of ten matched the best estimate of PN:KC convergence (Turner et al., 2007).”
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit. (2020, background): “The expansion in cell number is accompanied by an increase in response selectivity in the KCs, where only 5% of cells respond to a given odor, compared to 50% in the PNs (Honegger et al. 2011, Turner et al. 2008,Wilson et al. 2004).”
Odor representations in olfactory cortex: "sparse" coding, global inhibition, and oscillations. (2009, methodology): “A similar strategy has been used to explore the nature of stimulus representations in the insect olfactory system (Perez-Orive et al., 2002; Szyszka et al., 2005; Turner et al., 2008) and mammalian auditory cortex (Hromadka et al.”
γ neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila (2012, neutral): “Because perception of pure chemical odors is thought to be represented as sparse responses in populations of KCs [29, 30], we wondered whether the sufficiency of g lobes as a site of DopR input could derive from odor choice if OCT and MCH by chance triggered mostly g lobes responses.”