Shared mushroom body circuits underlie visual and olfactory memories in Drosophila

By K. Vogt, C. Schnaitmann, Kristina V. Dylla, Stephan Knapek, Yoshinori Aso, Gerald M. Rubin, Hiromu Tanimoto. 2014

196 citations recorded by the source corpus.

In nature, animals form memories associating reward or punishment with stimuli from different sensory modalities, such as smells and colors. It is unclear, however, how distinct sensory memories are processed in the brain. We established appetitive and aversive visual learning assays for Drosophila that are comparable to the widely used olfactory learning assays. These assays share critical features, such as reinforcing stimuli (sugar reward and electric shock punishment), and allow direct comparison of the cellular requirements for visual and olfactory memories. We found that the same subsets of dopamine neurons drive formation of both sensory memories. Furthermore, distinct yet partially overlapping subsets of mushroom body intrinsic neurons are required for visual and olfactory memories. Thus, our results suggest that distinct sensory memories are processed in a common brain center. Such centralization of related brain functions is an economical design that avoids the repetition of similar circuit motifs. DOI: http://dx.doi.org/10.7554/eLife.02395.001

Subfields: Cellular and Molecular Neuroscience, Ecology, Genetics

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Ecology

In Genetics

Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, methodology): “Sugar preference and shock avoidance tests were performed as described previously (Schnaitmann et al., 2010; Vogt et al., 2014).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “In Drosophila melanogaster, a number of different forms of learning have been observed in response to sensory stimuli (Siegel and Hall, 1979; Liu et al., 1999, 2006; Masek and Scott, 2010; Schnaitmann et al., 2010; Ofstad et al., 2011; Vogt et al., 2014).”
Modelling learning and memory in Drosophila to understand Intellectual Disabilities. (2020, unknown): “, 1999; Montague and Baker, 2016), visual and spatial learning (Wolf et al., 1998; Ofstad et al., 2011; Vogt et al., 2014), food-seeking behavior (Tsao et al.”
Reward signal in a recurrent circuit drives appetitive long-term memory formation (2015, unknown): “To target the expression specifically to the α/β KCs, we employed two driver lines, MB008B-GAL4 (Aso et al., 2014a; Vogt et al., 2014) (Figure 6—figure supplement 1A) and c739GAL4 (Yang et al., 1995).”
A Higher Brain Circuit for Immediate Integration of Conflicting Sensory Information in Drosophila. (2015, background): “What is the advantage of using theMB for adaptive behavior to innate odors? Given that the MB also integrates other sensory modalities including visual information [41], the dependence on theMB that we foundwould ensure that CO2 avoidance behavior is only suppressed when additional odor, taste, or v”