OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.

By Paul R. Rogers, Jianxun Song, I. Gramaglia, Nigel Killeen, Michael Croft. Immunity, 2001

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Similarities and differences in CD4+ and CD8+ effector and memory T cell generation (2003, background): “With regard to costimulatory molecules, there is evidence that OX-40 and OX-40 ligand may be involved in sustaining CD4 + T cell surviva”
The role of TNF superfamily members in T-cell function and diseases (2009, background): “The induction or upregulation of OX40, 4-1BB and DR3 expression occurs within 24 hours following the recognition of antigen by and activation of naive T cells, and much more rapidly by memory T cells; the expression of these receptors can last for several hours or even day”
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo (2002, background): “Signals derived from each of these receptors inhibit TCR-induced apoptosis and prolong surviva”
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1 (2003, background): “CD28-dependent OX40 induction on CD4 T cells has been implicated in promoting T cell survival and the generation of memory T cells (20, 21).”
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion (2002, background): “For example, triggering of CD28, 4-1BB and OX40 receptors costimulates growth of T cells and prevents the death of activated T cell”