The role of TNF superfamily members in T-cell function and diseases

By M. Croft. Nature reviews. Immunology, 2009

932 citations recorded by the source corpus.

Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand–receptor interactions — OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 — and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/3521fde7b983368edd26b17ddca1a4c45dfd49f1

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Citations in the corpus

Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications (2010, background): “As highlevel or chronic exposure to TNF-a has been shown to produce serious detrimental effects on the host [113], the magnitude of TNF-a and other pro-inflammatory cytokines, and their delivery to tumor sites will undoubtedly be important parameters when considering ZnO nanoparticles for biomedical”
Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging (2018, neutral): “sCD137 plasma levels positively associate with acute coronary syndromes (66) and atherothrombotic stroke (67), and we hypothesize that in vivo, γδ T cells produce sCD137 which is also known to trigger pro-inflammatory networks that involve macrophages and DCs (115) Also, our multivariate PSLR result”
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors. (2014, background): “Conversely, 4-1BB (also known as CD137) is a costimulatory member of the TNF receptor family that has emerged as an important mediator of survival and proliferation, particularly in CD8 + T cells (25–27).”
NF-κB signaling in inflammation (2017, neutral): “55 Although some of the TNFR ligands are also expressed on activated T cells, the T cell–”
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “TNFR family members OX40, 4–1BB, and CD27 are important costimulatory molecules involved in clonal expansion, differentiation, and survival of Teff cells (244).”
CD4+T Cells: Differentiation and Functions (2012, background): “These receptors have their ligands expressed on DC [17, 18].”