Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

By M. Gavin, Sally R. M. Clarke, E. Negrou, Alena M. Gallegos, Alexander Y. Rudensky. Nature Immunology, 2002

737 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/95b56a9b96c98624818ace6c2a89c97c833b808c

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In Immunology

Citations in the corpus

Regulatory T Cells and Foxp3 (2011, background): “Moreover, adoptive transfer of CD25 Treg cells into lymphopenic mice showed that they proliferate robustly in an major histocompatibility complex (MHC) class II-dependent manner and their suppressor capacity increases despite a decline in expression of CD25 (6).”
Cyclic adenosine monophosphate is a key component of regulatory T cell–mediated suppression (2007, result): “This fi nding was in agreement with recently published data (13) and led us to suggest that naturally occurring T reg cells harbor high concentrations of cAMP that profoundly suppress the production of IL-2 in naturally occurring T reg cells, which is a characteristic feature of this T cell populati”
CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness (2002, background): “Resting CD4� CD25� T cells selectively express high levels of mRNA for Tgif, a transcriptional corepressor that suppresses TGF-� 1‐induced transcription (44, 45 ).”
Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo (2003, background): “7, transgene-negative littermates), in line with previous observations by others (9).”
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells (2003, background): “CD4 + CD25 + T cells do not proliferate following agonistic T cell receptor (TCR) ligation, however they are capable of rapid expansion in lymphopenic host animal”