Design and selection of novel Cys2His2 zinc finger proteins.

By C. Pabo, E. Peisach, R. Grant. Annual Review of Biochemistry, 2001

717 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/58977193811df136fde3bb8e8e631f26bf6eff6c

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Citations in the corpus

TALENs: a widely applicable technology for targeted genome editing (2012, neutral): “83, 84 Engineered zinc fingers can be joined together into more extended arrays capable of recognizing longer DNA sequences.”
Gene targeting using zinc finger nucleases (2005, background): “The appeal of ZFNs, however, is that the zinc finger DNA binding domain could be modified to recognize novel target sequences, including those in endogenous gene”
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases (2009, background): “Although it is possible that not all nonexpressed genes can be targeted by ZFNs, the extraordinary flexibility available in designing zinc-finger binding motif”
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. (2007, neutral): “Moreover, the few amino acid substitutions within the CTCF DNA-binding domain do not map to any residues predicted to make direct contacts with the DNA (Pabo et al., 2001).”
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery (2007, background): “is engineered to recognize a DNA sequence of interes”
Highly efficient endogenous human gene correction using designed zinc-finger nucleases (2005, background): “, and several fingers can be linked in tandem to recognize a broad spectrum of DNA sequences with high specificit”
A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions (2012, background): “Given that TFs containing ZFs play a central role in eukaryotic promoter regulation (Pabo et al., 2001), our system represents a promising means for synthetic recapitulation of eukaryotic promoter function, and thus will signiﬁcantly enhance our ability to construct synthetic gene networks in…”
Heritable Targeted Gene Disruption in Zebrafish Using Designed Zinc Finger Nucleases (2008, background): “The C 2 H 2 zinc finger is a versatile DNA binding motif capable of recognizing a broad range of sequence”
Arabidopsis Cys2/His2-Type Zinc-Finger Proteins Function as Transcription Repressors under Drought, Cold, and High-Salinity Stress Conditions1 (2004, background): “This motif is represented by the signature CX24CX3FX5LX2HX3-5H, consisting of about 30 amino acids and 2 pairs of conserved Cys and His bound tetrahedrally to a zinc ion (Pabo et al., 2001).”