Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

By C. Png, S. Lindén, K. Gilshenan, Erwin G. Zoetendal, C. McSweeney, L. Sly, M. McGuckin, T. Florin. American Journal of Gastroenterology, 2010

1,275 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/57e42e8a2f54737098cc94bbe32d449c0cd70289

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Citations in the corpus

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “IBD patients exhibit reduced intestinal mucosal barriers and decreased mucin glycosylation, and the disproportionate increase in several mucolytic microbes in IBD is suggested to be partly due to bacterial adaptation to the altered mucin glycosylation (Png et al., 2010).”
Stool Microbiome and Metabolome Differences between Colorectal Cancer Patients and Healthy Adults (2013, background): “This bacterium is a common member of the colonic microbiota and was recently shown to be reduced in irritable bowel syndrome and Crohn’s Disease [32]; however a more recent report showed increased A. muciniphila in ulcerative colitis-associated pouchitis [33].”
Akkermansia muciniphila is a promising probiotic (2019, background): “…muciniphila is abundant in the gut microbiota of healthy individuals and exerts the effect of preventing and treating obesity, type 2 diabetes and other metabolic dysfunctions (Png et al., 2010, Santacruz et al., 2010; Karlsson et al., 2012; Everard et al., 2013; Zhang et al., 2013).”
Mechanisms of Disease: Inflammatory Bowel Diseases. (2019, background): “Lastly, the number of sulfate-reducing bacteria, such as Desulfovibrio, is also increased in IBD resulting in the production of hydrogen-sulfate that damages the intestinal barrier and allows activation of mucosal inflammation (57).”
The Controversial Role of Human Gut Lachnospiraceae (2020, background): “The disruption of the mucus layer might promote bacterial translocation and has been associated with IBD and CD [158,159].”
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. (2017, background): “, 2011), and it has been postulated that themicrobial changes seen in IBD are in part due to bacterial adaptation to the changes in mucin glycosylation (Png et al., 2010).”
Microbes inside—from diversity to function: the case of Akkermansia (2012, background): “muciniphila and its localization within the mucus layer reveal its specific niche and function within the gut (Swidsinski et al., 2009, 2011; Png et al., 2010).”
Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model (2012, background): “As colonization of mucus by different mucolytic species may be crucial with respect to human health (Png et al., 2010), the M-SHIME may be improved by adding a distal colon region.”
Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics (2017, background): “adolescentis (Martinez-Medina et al., 2006; Png et al., 2010; Joossens et al., 2011), as well as other bacterial indicators of gut health such as Akkermansia muciniphila (Png et al.”