Molecular mechanisms of antibody somatic hypermutation.
By J. D. Di Noia, M. Neuberger. Annual Review of Biochemistry, 2007
1,095 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/57184c42dc186d4be826bbc441d82fe1206e265d
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In Immunology
- Jeffrey J. Gray
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In Molecular Biology
- M. Lamkanfi
- Jeffrey J. Gray
- Daisuke Kuroda
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- R. Dalla-Favera
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Citations in the corpus
- Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “…the 5mC reactivity for AID deamination in vitro is much lower than unmethylated cytosines (Bransteitter et al., 2003; Conticello et al., 2007; Di Noia and Neuberger, 2007; Larijani et al., 2005), raising the question of whether AID, if it does initiate demethylation, directly deaminates 5mCs in…”
- Naïve Human Antibody Libraries for Infectious Diseases (2018, background): “Naïve antibody libraries are constructed using B cells of unimmunized or healthy donors, normally focusing on the IgM isotype.”
- Germinal centres: role in B-cell physiology and malignancy (2008, background): “Then, error-prone repair that involves different DNA repair factors leads to the introduction of somatic mutations (reviewed in Ref”
- MicroRNA control in the immune system: basic principles. (2009, background): “Curiously, a potential target of this miRNA is the enzyme AID, a central player in the germinal center reaction, mediating class switch recombination (CSR) and somatic hypermutation (SHM) (Chaudhuri and Alt, 2004; Di Noia and Neuberger, 2007; Honjo et al., 2004).”
- Genome instability: a mechanistic view of its causes and consequences (2008, background): “Such events are triggered by the B-cell-specific enzyme AID, which deaminates dCs into dUs in actively transcribed DNA (reviewed in Ref”
- Inflammasomes and their roles in health and disease. (2012, background): “Through the process of somatic recombination, adaptive immune cells can generate an endless repertoire of antigen-specific receptors and highly specific antibodies against the presented molecules (Call & Wucherpfennig 2005, Di Noia & Neuberger 2007).”
- Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does Not Typically Result in Rigidification (2017, background): “Since our observations did not indicate clear rigidification over two sets of antibodies, we considered the following possibilities: (1) comparison of different length CDR-H3 loops was unfair because longer loops are inherently more flexible, (2) comparison of different antibodies was unfair because”