The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review)

By F. Ardito, M. Giuliani, D. Perrone, G. Troiano, L. Muzio. International Journal of Molecular Medicine, 2017

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Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ce927241a4df9f4cee0d59fcda7ba444ecc273ad