Purification and unique properties of mammary epithelial stem cells

By J. Stingl, P. Eirew, Ian Ricketson, Mark Shackleton, F. Vaillant, D. Choi, H. Li, C. Eaves. Nature, 2006

1,642 citations recorded by the source corpus.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/55630cfb6de7e74bad11e35646c72878e00a1283

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In Oncology

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Citations in the corpus

• Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. (2010, background): “…140, 62–73, January 8, 2010 ª2010 Elsevier Inc. approaches, based on the exploitation of MSC surface markers, have allowed the prospective isolation of mouse and human MSCs (Eirew et al., 2008; Liao et al., 2007; Lim et al., 2009; Raouf et al., 2008; Shackleton et al., 2006; Stingl et al., 2006).”
• Epithelial stem cells: turning over new leaves. (2007, positive): “They also appear to be slow-cycling cells, able to retain nucleotide label over an extended pulse-chase, and they express a number of genes that are also upregulated in bulge stem cells (Blanpain et al., 2004; Morris et al., 2004; Stingl et al., 2006; Tumbar et al., 2004).”
• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers (2009, positive): “Results Identification of three distinct human breast epithelial subsets To delineate epithelial subpopulations in human mammary tissue, we used an analogous approach to that previously described for the mouse mammary stem cell (MaSC”
• Diffusion maps for high-dimensional single-cell analysis of differentiation data (2015, background): “Moreover, stem cell populations that have been functionally characterised often show heterogeneity in their cellular and molecular properties (Huang, 2009; Dykstra et al., 2007; Stingl et al., 2006).”
• Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “Cultured myoepithelial-enriched cells express CK14 but not CK8/18 or CK19 (Cho et al., 2008; Stingl et al., 2006).”
• Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “Following implantation of bona fide mammary stem cells, entire mammary ductal trees will grow out over a period of six to eight weeks that are indistinguishable from those formed during normal mammary gland morphogenesis (Shackleton et al., 2006; Stingl et al., 2006).”
• Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation (2007, background): “All three epithelial cell types have recently been demonstrated to originate from a common multipotential stem cel”
• The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, positive): “(D) The expression levels of the mRNAs encoding E-cadherin, N-cadherin, vimentin, Slug, and Twist in the CD49fhigh/CD24med relative to CD49fhigh/ CD24med-depleted cells, as determined by realtime RT-PCR.”
• Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. (2009, background): “Mouse MaSCs are highly enriched in the CD49fCD29CD24Sca1 subset (referred to as MaSCenriched) and can generate extensive ductal outgrowths upon transplantation (Shackleton et al. 2006; Sleeman et al. 2006; Stingl et al. 2006).”
• Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling (2017, methodology): “out as described previously (4, 5), and as described in SI Experimental Procedures.”
• Wnt signaling: is the party in the nucleus? (2006, background): “Recently, a discrete population of mammary stem cells was identified and shown to be able to reconstitute a complete mammary gland in vivo (Shackleton et al. 2006; Stingl et al. 2006).”