Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

By E. Lim, F. Vaillant, Di Wu, N. Forrest, B. Pal, Adam H. Hart, Marie-Liesse Asselin-Labat, D. Gyorki, T. Ward, Audrey Partanen and 10 more. Nature Medicine, 2009

1,475 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/290ce394c32445532e9ab807acb03ad152dc26bc

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Citations in the corpus

The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “…are all able to alter their gene expression to resemble cell types that are not part of their original lineage (Quail et al., 2012) exemplifies cancer cell plasticity that enables cancer cells to gain/lose stem cell properties (Shirakawa et al., 2002; Passalidou et al., 2002; Lim et al., 2009).”
Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. (2010, background): “…140, 62–73, January 8, 2010 ª2010 Elsevier Inc. approaches, based on the exploitation of MSC surface markers, have allowed the prospective isolation of mouse and human MSCs (Eirew et al., 2008; Liao et al., 2007; Lim et al., 2009; Raouf et al., 2008; Shackleton et al., 2006; Stingl et al., 2006).”
EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “(Gupta et al., 2005; Ince et al., 2007; Lim et al., 2009; Molyneux et al., 2010; Proia et al., 2011).”
Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients (2014, positive): “…cancers belong to the Claudin-Low subtype and are likely derived from the highly plastic cells of the basal layer of the mammary gland; the less plastic luminal cells, in contrast, are thought to give rise to the Basal subtype (Taddei et al , 2008; Lim et al , 2009; Molyneux et al , 2010) (Fig 2B).”
Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists (2011, background): “14 This has been emphasized in a recent study, which suggested that at least a subgroup of basal-like breast cancers may originate from luminal progenitors rather than basalsmyoepithelial cells of the breast”
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. (2009, background): “For example, CD24 is a pan-epithelial marker in the mouse mammary gland, but not in human breast tissue where it serves exclusively as a luminal marker (Shackleton et al. 2006; Stingl et al. 2006; Raouf et al. 2008; Lim et al. 2009).”
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state (2011, methodology): “It is becoming apparent, however, that the differentiation states of cells-of-origin can influence the organization of derived neoplastic cell populations (8, 9).”
Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “Experimental models suggest that basal breast cancers arise from luminal progenitors and that mutations in genetic drivers of breast cancer, such as BRCA1, can shift luminal progenitors toward basal differentiation (Lim et al., 2009; Molyneux et al., 2010).”
limma powers differential expression analyses for RNA-sequencing and microarray studies (2015, positive): “Although roast can be used to test a large number of gene sets, roast is most useful for linking different datasets by finding similarities in gene expression patterns using gene weights from other differential expression analyses [31, 30, 4, 74].”
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs (2011, background): “, which is the presumptive origin of basal breast carcinoma”
From RNA-seq reads to differential expression results (2010, background): “Examples include defining the cell of origin for breast cancer subtypes [78] and investigating the effect of evolution on gene expression in Drosophila [79].”
Camera: a competitive gene set test accounting for inter-gene correlation (2012, methodology): “Expression values were normalized and filtered as described previously (31).”