Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

By D. Selkoe, Raphael Kopan. Annual Review of Neuroscience, 2003

708 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/55261c4ffb2f396968ab216d82dd211af2678561

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

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Citations in the corpus

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. (2005, background): “The ratio of Aβ40, a resident peptide of AD blood vessels, to Aβ42, which aggregates at lower concentrations than Aβ40 and is enriched within the amyloid plaque of AD (23, 24), was about 10:1 throughout this 8-week period.”
Engineering T cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors (2016, positive): “When it engages the cognate antigen, the synNotch receptor undergoes induced transmembrane cleavage, akin to native Notch activation (Bray, 2006; Selkoe and Kopan, 2003), thereby releasing the intracellular transcriptional domain to enter the nucleus and activate expression of target genes regulated”
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy (2009, background): “Mutations associated with early-onset familial AD (FAD) are dominantly inherited and are found in the APP gene itself or in the presenilin 1 ( PSEN1 ) and PSEN2 genes, the products of which, together with nicastrin , APH1 and PSENEN2 , are essential components of a protein complex that i”
The Hes gene family: repressors and oscillators that orchestrate embryogenesis (2007, background): “Notch signaling Notch family members are type I transmembrane receptors for the DSL (Delta, Serrate, Lag-2) family of type I transmembrane ligands (Artavanis-Tsakonas et al., 1999; Selkoe and Kopan, 2003).”
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation (2004, background): “The basic helix-loop-helix genes Hes1 and Hes5 are essential effectors for Notch signalling, which regulates the maintenance of undifferentiated cells (Artavanis-Tsakonas et al., 1999; Gaiano and Fishell, 2002; Hitoshi et al., 2002; Honjo, 1996; Kageyama and Nakanishi, 1997; Selkoe and Kopan, 2003).”
Trafficking and proteolytic processing of APP. (2012, background): “2011), a cellular process, which is frequently involved in important signaling pathways (Selkoe and Kopan 2003; see DeStrooper et al. 2011).”
[P2.15]: Oscillations in notch signaling regulate maintenance of neural progenitors (2008, positive): “Upon activation of Notch signaling by its ligands, such as Delta-like1 (Dll1), the intracellular domain of the transmembrane protein Notch (NICD) is released from the membrane region and transferred into the nucleus, where the NICD converts RBP-J from a repressor to an activator by forming a complex”