The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF1

By Kai‐Uwe Belge, Farshid Dayyani, Alexia Horelt, M. Siedlar, M. Frankenberger, B. Frankenberger, T. Espevik, Löms Ziegler-Heitbrock. Journal of Immunology, 2002

921 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/552470d0b5fb10e93c049f5792e011181e831ffd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors (2010, positive): “Human CD16 monocytes, which resemble Gr1 cells, are described as the main producers of inflammatory cytokines such as TNF-a and IL-1b in response to bacterial lipopolysaccharides (LPSs) (Belge et al., 2002).”
Cellular and molecular mechanisms of skin wound healing (2024, neutral): “109).”
Efficient clearance of early apoptotic cells by human macrophages requires “M2c” polarization and MerTK induction (2012, result): “IL-10 and TNF-a levels were measured in supernatants using human IL-10 ELISA MAX Standard kit and TNF-a ELISA MAX Standard kit (BioLegend), following the manufacturer’s instructions.”
Blood monocytes: development, heterogeneity, and relationship with dendritic cells. (2009, background): “In contrast to this major subset, human CD16+ monocytes express high levels of CX3CR1 and low levels of CCR2 (10, 109, 118), are responsible for the production of TNF-α in response to LPS stimulation, and were called proinflammatory (101, 119).”
Monocyte-mediated defense against microbial pathogens. (2008, background): “CD16+ monocytes increase in frequency during infections (6,7), produce high levels of tumor necrosis factor (TNF) and low levels of IL-10 upon stimulation with Toll-like receptor (TLR) agonists (8), and therefore are also referred to as proinflammatory monocytes.”
Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes (2003, background): “Stimulation by TNF- induced comparable levels of CD62E, ICAM-1, and VCAM-1 expression on iHUVEC and pHUVEC (Fig.”
The three human monocyte subsets: implications for health and disease (2012, methodology): “This subset is generally termed ‘‘pro-inflammatory’’ monocytes because of their ability to produce high amounts of TNF-a and IL-1b [18, 19].”