Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

By J. Kordower, M. Emborg, J. Bloch, Shuang Y. Ma, Y. Chu, L. Leventhal, J. McBride, E. Chen, S. Palfi, Ben Roitberg and 10 more. Science, 2000

1,273 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/55154615b057773cb61a6e67bc734ced70951f3b

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease (2003, background): “Intraparenchymal delivery is effective whether by bolus injection, by chronic infusion using a pump or by infecting the brain with live replication-deficient viral particles engineered to deliver GDN”
Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD (2011, methodology): “Primates: two adult (17–18 year old; 10–12 kg; female) rhesus monkeys were rendered hemiparkinsonian via carotid MPTP administration followed by weekly intravenous MPTP administration to create a bilateral parkinsonian syndrom”
Past, Present, and Future of Parkinson’s Disease: A Special Essay on the 200th Anniversary of the Shaking Palsy (2017, positive): “Enthusiasm for this approach then waned until the demonstration that intrastriatal gene delivery of GDNF could augment nigrostriatal function in aged monkeys and prevent the structural and functional consequences of MPTP-induced parkinsonism in nonhuman primates.(280) This led to open-label and doub”
Progress and problems with the use of viral vectors for gene therapy (2003, neutral): “gov/htbin-post/Omim/dispmim?168600">Parkinson disease”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “Therapeutic effects of BDNF In addition to their major roles in supporting neuronal survival and function during development and in adulthood, nervous system growth factors exert potent pro-survival and functional effects in models of neurological disease (for example, striking effects hav”
Parkinson's Disease Mechanisms and Models (2003, methodology): “…to 1-methyl-4-phenyl-2,3-dihydropyri-induced nigrostriatal dopaminergic neurodegeneration dinium (MPDP ) by monoamine oxidase B (MAO-B) inand can lead to behavioral recovery when given to preglia and serotonergic neurons, the only cells that containviously lesioned animals (Kordower et al., 2000).”
Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease (2006, neutral): “Catheter tract Fluid collection 1 (3) 1 (1) Pump Migration 2 (6) 4 (6) Pump pocket Fluid collection 1 (3) 2 (3) Hematoma 1 (3) 1 (1) Infection 1 (3) 2 (3) Surgery/anesthesia Intracranial hemorrhage 1 (3) 1 (1) Other postoperative pain 1 (3) 2 (3) Other Amnesia 1 (3) 2 (3) Muscle spasms 1 (3) 1 (1) M”
Ageing and neuronal vulnerability (2006, background): “, and neurotrophic factor therapies for PD, HD and AL”