Mechanisms of alternative pre-messenger RNA splicing.

By Douglas L. Black. Annual Review of Biochemistry, 2003

2,795 citations recorded by the source corpus.

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Citations in the corpus

Ending the message: poly(A) signals then and now. (2011, background): “In the case of alternative splicing, regulation of this RNA processing mechanism is often achieved by the enhancement of weak splice sites by so-called splicing enhancers (often in adjacent exons) that are recognized by splicing regulatory factors (usually SR proteins) (Black 2003).”
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches (2009, background): “Recent estimates indicate that the expression of nearly 95% of human multi-exon genes involves alternative splicin”
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007, background): “Data presented in this study and in a number of earlier reports (Black, 2003; Spellman and Smith, 2006; Wagner and Garcia-Blanco, 2001) implicate PTBP1 as a global repressor of NS-specific alternative splicing.”
Opportunities and challenges Genome-wide analyses of alternative splicing in plants: (2008, positive): “A potentially large number of alternatively spliced mRNAs can be created by these mechanisms both singularly or in combination (Black 2003; Sorek et al. 2004).”
Function of alternative splicing. (2005, positive): “described as consensus sequences that are loosely followed (Black, 2003).”
Alternative Isoform Regulation in Human Tissue Transcriptomes (2008, methodology): “Columns 1–4 show the numbers of events of each type: (1) supported by cDNA and/or EST data; (2) with $1 isoform supported by mRNA-Seq reads; (3) with both isoforms supported by reads; and (4) events detected as tissueregulated (Fisher’s exact test) at an FDR of 5% (assuming negligible technical vari”
Computational definition of sequence motifs governing constitutive exon splicing. (2004, background): “Alternatively spliced exons are usually associated with weak splice sites (Black 2003), so it is possible that their selection method was biased toward this class of exons.”
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells (2009, neutral): “A dominant function of these RNA binding proteins is to regulate alternative splicing, a major form of post-transcriptional regulation of gene expression that is thought to contribute to the structural and functional diversity of the cellular proteom”
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (2006, methodology): “Four splice signals are essential for accurate splicing: the 5 0 and 3 0 splice site (5 0 ss and 3 0 ss), the polypyrimidine tract, and the branch site sequence (Black, 2003).”
Aberrant and Alternative Splicing in Cancer (2004, background): “The definition of alternative splicing is the process whereby identical pre-mRNA molecules are spliced in different ways, and this is important in normal development as a means of creating protein diversity in complex organisms (14, 15).”
Variation in alternative splicing across human tissues (2004, background): “In addition to many differences between tissues in transcriptional and translational regulation of genes, alternative pre-mRNA splicing (AS) is also frequently used to regulate gene expression and to generate tissue-specific mRNA and protein isoforms [1-5].”
The spliceosome: design principles of a dynamic RNP machine. (2009, background): “The SR protein ASF/SF2 and hnRNP A1 are a well-characterized example of factors that exhibit antagonistic effects (Black, 2003; Caceres et al., 1994; Zhu et al., 2001).”
Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. (2005, background): “…flanking (and within) alternatively spliced exons—which are believed to mediate splicing by weakly binding various interacting proteins (e.g., Black 2003)—may tend to be conserved because they have been fine tuned by evolution to promote splicing in certain tissue types or development…”