The spliceosome: design principles of a dynamic RNP machine.

By M. Wahl, C. Will, Reinhard Lührmann. Cell, 2009

2,628 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/51f3d09ad3cd4573c8a4c8e92356b1137a6492ac

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In Molecular Biology

Citations in the corpus

RNA-Binding Proteins in Cancer: Old Players and New Actors. (2017, background): “The spliceosome is a large RNP complex involved in splicing the removal of non-coding introns from precursor messenger RNAs (pre-mRNAs) (reviewed in [37]).”
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. (2010, background): “Pre-mRNA splicing, the joining of two exons accompanied by the removal of intronic sequence, requires a very large ribonucleoprotein (RNP) complex termed the spliceosome (Wahl et al. 2009).”
Small molecule modulators of pre-mRNA splicing in cancer therapy (2015, background): “The binding is then stabilized by SF3Ba and SF3Bb [2].”
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution (2010, background): “Splice-site selection is primarily mediated by RNA-binding proteins that bind regulatory elements within nascent transcript”
RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES (2011, background): “POU4F1 is associated with t(8;21) acute myeloid leukemia and contributes directly to its unique transcriptional signature.”
Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution. (2019, background): “They thus act mainly at the early stages of spliceosome formation, although regulation can also be imparted at later stages of assembly (Wahl et al., 2009).”
The nuts and bolts of the endogenous spliceosome (2017, methodology): “The assembly of the spliceosome in vitro occurs in a step-wise manner (reviewed in Refs 2,4), and involves an intricate series of interactions between the five major U snRNPs, as well as with a number of nonsnRNP splicing factors, which are dynamically recruited to the spliceosome when an exogenous ”
Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis (2012, background): “The splicing process, removal of introns and ligation of exons, is performed by a large RNA-protein complex, the spliceosome, consisting of five small nuclear RNAs (snRNAs) and about 180 proteins with different functions (Wahl et al. 2009).”
Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses[OPEN] (2013, background): “It consists of five small nuclear ribonucleoprotein particles (snRNPs) and over 200 additional proteins (Wahl et al., 2009; Will and Lührmann, 2011; Koncz et al., 2012; Reddy et al., 2013).”
Mechanisms and Regulation of Alternative Pre-mRNA Splicing (2015, background): “They have also enabled the structural analysis of these staged complexes using electron microscopy methods (11, 12).”
A census of human RNA-binding proteins (2014, background): “example, the abundance of various splicing factors can influence mRNA splicing patterns (Chen and Manley, 2009; Kalsotra and Cooper, 2011; Kornblihtt et al., 2013; Smith and Valcarcel, 2000; Wahl et al., 2009), while U1 snRNP levels control alternative polyadenylation sites (Berg”