Aberrant and Alternative Splicing in Cancer

By J. Venables. Cancer Research, 2004

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Intrinsically disordered proteins in human diseases: introducing the D2 concept. (2008, background): “Because AS affects many protein functions such as ligand binding, enzymatic activity, and proteinprotein interactions, it is not surprising that abnormal AS has been associated with human diseases, including myotonic dystrophy (111), azoospermia (89), AD (76), cancer (123, 149), and many others.”
EMT and tumor metastasis (2015, background): “CD44 is not, by any means, the only example of alternative splicing affecting EMT [38].”
The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007, background): “Thus, changes in the expression of these proteins can affect the alternative splicing of an undefined number of cellular transcripts and might account for some of the known splicing changes in cance”