Endothelial cell diversity revealed by global expression profiling

By J. Chi, Howard Y. Chang, G. Haraldsen, F. Jahnsen, Olga G. Troyanskaya, Dustin S. Chang, Zhen Wang, S. Rockson, M. van de Rijn, David Botstein and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2003

778 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/53991beedcceb846531374313b435fb7d548af51

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. J. Chiu
2. Asrar B. Malik
3. W. Aird
4. Shu Chien
5. S. Verma
6. Jonathan W. Yau
7. H. Teoh
8. D. Mehta

In Molecular Biology

1. Asrar B. Malik
2. W. Aird
3. D. Mehta
4. Stefanie Dimmeler
5. J. Chiu
6. Shu Chien
7. A. Zeiher
8. S. Verma

Citations in the corpus

• Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, neutral): “macrovascular (78) but also tissue-related variations (23).”
• Endothelial cell control of thrombosis (2015, background): “Microvascular endothelial cells within arteries and veins have distinctive features [15].”
• The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. (2004, background): “A recent microarray comparison of a large series of human endothelial cell lines confirmed an arterial-specific expression for Hey2 (Chi et al. 2003).”
• Signaling mechanisms regulating endothelial permeability. (2006, background): “(163, 917), whereas a greater contribution of fibronectin,”
• Vascular Endothelial Cell Biology: An Update (2019, background): “A comparison of cultured EC from arteries, veins, and micro-vessels revealed that not only arteries and veins but in particular, microvascular EC displayed distinct differences showing specific genomic properties and other differences at the tissue level [106].”
• SIRT1 controls endothelial angiogenic functions during vascular growth. (2007, background): “…Hey2, which is the human homolog of the zebrafish gene gridlock, is an important regulator of endothelial gene expression and differentiation (Chi et al. 2003), and mice homozygous for a combined loss of Hey1 and Hey2 are embryonically lethal due to defects in vascular development (Fischer…”
• Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. (2005, background): “Also, significant differences exist between large-vessel and microvascular endothelium [13–15].”
• Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives (2011, background): “The notion of phenotypic diversity of ECs arises from both in vivo (510, 538) and cell culture studies (60, 84, 146, 567), which indicate that there are substantial differences in gene expression between ECs from different vascular sites.”
• Endothelial cell heterogeneity (2003, background): “A previous DNA microarray study of multiple human endothelial cell types grown in culture revealed site-specific signatures even in multiple passaged cells, providing genomewide evidence for the importance of epigenetics in mediating differential gene expression (Chi et al. 2003).”
• Arteriolar niches maintain haematopoietic stem cell quiescence (2013, positive): “These differing characteristics translate into significant differences in the transcriptional program of arteriolar and venular endothelial cells 39 .”