Patched1 Regulates Hedgehog Signaling at the Primary Cilium
By R. Rohatgi, Ljiljana Milenkovic, M. P. Scott. Science, 2007
624 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/537b048125dbc641f04e9389466bba2d412e5b4f
Citations in the corpus
- Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells (2008, neutral): “Consistently, essential Shh signaling components, Patched (Ptc), Smo, Suppressor of fused and Gli transcription factors, concentrate in primary cili”
- The Primary Cilium: A Signaling Center During Vertebrate Development (2010, neutral): “Two transmembrane proteins, PTCH1 (the Hh receptor) and SMO (which acts downstream of PTCH1), show dynamic, Hh-dependent trafficking in cili”
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network (2008, neutral): “Heparan sulfate proteoglycans (HSPGs), components of the extracellular matrix, bind ShhNp at a conserved site (Rubin et al., 2002).”
- Hedgehog Signaling in Development and Cancer (2008, neutral): “Ciliary localization of Smo correlates with Hh pathway activation: both an oncogenic Smo mutation and Smo agonists, such as SAG and oxysterols, promoted accumulation of Smo in the cilia (Corbit et al., 2005; Rohatgi et al., 2007).”
- Mechanisms and functions of Hedgehog signalling across the metazoa (2011, neutral): “In mammalian cells, exposure to HH ligand causes SMO to localize to the axoneme of the primary ciliu”
- Hedgehog: functions and mechanisms. (2008, neutral): “2005); in the absence of Shh, this accumulation is prevented by Ptc (Rohatgi et al. 2007).”
- Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “The primary cilium also functions as an antenna for specific signaling pathways – this structure has been implicated in Hedgehog (Hh), Wnt, and PDGF signaling, which are thought to occur in this region (Corbit et al., 2005; Jackson et al., 2006; Eggenschwiler and Anderson, 2007; Rohatgi et al., 2007”