Induction of Tumors in Mice by Genomic Hypomethylation

By François Gaudet, J. Hodgson, A. Eden, L. Jackson‐Grusby, J. Dausman, Joe W. Gray, Heinrich Leonhardt, R. Jaenisch. Science, 2003

1,424 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5368850f318b5e6e7402d966d4b4fafee79fd347

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Citations in the corpus

Epigenetic Determinants of Cancer. (2016, background): “Indeed, deletion or reduction of the maintenance DNA methyltransferase, Dnmt1, results in increased mutation rates, aneuploidies, and tumor induction, a clear indication that DNA hypomethylation plays an active role in increasing chromosomal fragility (Chen et al. 1998; Narayan et al. 1998; Gaudet e”
DNA hypomethylation and human diseases. (2007, background): “Some of these events have been observed in vitro and using in vivo animal models [20,27–30], but their relative importance in human disease is not understood.”
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine (2008, background): “Mouse models with strongly and permanently reduced DNA methylation levels have shown genetic amplification and insertional activation of oncogenic loci.(30,31) These events are probably linked to the epigenetic reactivation of mobile DNA elements and need to be monitored and minimized during demethy”
The history of cancer epigenetics (2004, result): “These results indicate that hypomethylation might abate the risk of cancer, but more recent studies from Jaenisch and colleagues indicate just the opposite, with a high frequency of lymphomas in mice with a hypomorphic Dnmt1 allel”
Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “In mice, DNA hypomethylation is sufficient to induce aggressive T-cell lymphomas with a high frequency of chromosome 15 trisomy (Eden et al., 2003; Gaudet et al., 2003), whereas tumor suppressor genes are usually silenced by site-specific DNA hypermethylation at their promoters (Esteller et al.”
Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms (2003, background): “Genomic hypomethylation in these mice leads to tumour formation and to marked chromosome instabilit”
DNA methylation and cancer. (2004, background): “mice developed aggressive T-cell lymphomas that displayed a high frequency of chromosome 15 trisomy.(22) Therefore,”
Phenotypic plasticity and the epigenetics of human disease (2007, background): “Hypomethylation also causes increased chromosomal instability, leading to aggressive T-cell lymphoma”
Intra-individual change over time in DNA methylation with familial clustering. (2008, positive): “Similarly, animal studies have shown that a loss of DNA methylation increases intestinal adenoma initiation and a gain of DNA methylation increases adenoma progression.(29) Similarly, both hypomethylation and hypermethylation could lead to autoimmune disease by activating autoreactivity genes or sil”
DNA methylation aging clocks: challenges and recommendations (2019, background): “Repetitive regions possess latent functionality [152, 153], however are robustly epigenetically repressed by DNA methylation [151, 154, 155].”