Intra-individual change over time in DNA methylation with familial clustering.

By MD Hans T. Bjornsson, PhD Martin I. Sigurdsson, M. D. Fallin, PhD Rafael A. Irizarry, PhD Thor Aspelund, Peng Cui, Phyllis W. Yu, PhD Michael A. Rongione, BA Tomas J. Ekström, P. T. Harris and 7 more. Journal of the American Medical Association (JAMA), 2008

713 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/031ab46ae596950027895acac6dd198e6e12f931

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Steve Horvath
2. Peter Langfelder
3. K. van Eijk
4. Brock C. Christensen
5. M. Fraga
6. Eugene Andres Houseman
7. Carmen J. Marsit
8. Margaret R. Karagas

In Molecular Biology

1. Steve Horvath
2. Peter Langfelder
3. Christoph Bock
4. M. Boks
5. René S. Kahn
6. Roel A. Ophoff
7. L. H. van den Berg
8. K. van Eijk

Citations in the corpus

• Aging effects on DNA methylation modules in human brain and blood tissue (2012, background): “A genomewide decrease in DNA methylation has been shown to occur during in vitro aging [5] and in vivo aging [6,7].”
• Analysing and interpreting DNA methylation data (2012, background): “First, inter‑individual variation in DNA methylation is common among healthy individuals and appears to be heavily influenced by underlying genetic differences 121–125 .”
• DNA methylation age of human tissues and cell types (2013, background): “particular, cancer tissues were excluded from this first large data set since it is well known that cancer has a profound effect on DNA methylation levels [6,7,24-26].”
• Child health, developmental plasticity, and epigenetic programming. (2011, background): “The relative importance of genetic and nongenetic components in aging can be estimated from the results of twin studies (174, 175, 339, 343).”
• Persistent epigenetic differences associated with prenatal exposure to famine in humans (2008, result): “Our results do not exclude the occurrence of epigenetic changes later in development (20) or during aging (21).”
• Epigenetics and the environment: emerging patterns and implications (2012, background): “Besides the developmental ontogeny of epigenetic modifications, there is also considerable stochastic variation, often without apparent biological purpos”
• Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context (2009, background): “methylation levels (enriched for promoter regions) in peripheral blood cell DNA over time [20].”