Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

By J. O’Shea, M. Gadina, Robert Schreiber. Cell, 2002

1,207 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/522bf85cea642c41c81730de32e2e17b6fcadcb9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. M. Karin
2. T. Hirano
3. J. O’Shea
4. T. Lawrence
5. V. Nizet
6. A. Laurence
7. Y. Kanno
8. E. Shevach

In Pharmacology

1. M. Karin
2. J. O’Shea

Citations in the corpus

• Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, neutral): “Examination of SMAD3 and OCT4 binding at individual hESC genes revealed that SMAD3 occupies sites with OCT4; for example, the two transcription factors bind the same sites at POU5F1 and LEFTY1 (Figure 1B).”
• IL-6 signal transduction and its physiological roles: the signal orchestration model. (2003, background): “So far, seven STAT proteins (STAT1 to 4, 5a, 5b, and 6) have been identified in humans and mice (reviewed by Bromberg and Darnell 2000; O’Shea et al. 2002).”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “305 These cytokines and growth factors have corresponding receptors on the cell membrane.”
• The JAK-STAT Signaling Pathway: Input and Output Integration1 (2007, neutral): “Genetic studies have established that the cytokine receptor system is restrictive in that different classes of receptors preferentially use one JAK or JAK combination (7): receptors required for hemopoietic cell development and proliferation use JAK2, common -chain receptors use JAK1 and JAK3 wherea”
• The JAK/STAT signaling pathway (2004, neutral): “In addition to RTK and PI3K interactions with JAK/STAT signaling, multiple levels of cross-talk with the TGF-β signaling pathway have been recently reported [for a review of TGF-β, see ( Moustakas, 2002 )].”
• Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. (2006, background): “IL-10 and the structurally-related type I interferons (IFNs), as well as IL-6, IL-12, and many other cytokines, signal via receptor associated TKs that belong to the JAK group, whose activation results in phosphorylation and nuclear translocation of STAT transcription factors (O’Shea et al., 2002).”