IL-6 signal transduction and its physiological roles: the signal orchestration model.

By D. Kamimura, K. Ishihara, T. Hirano. Reviews of Physiology, Biochemistry and Pharmacology, 2003

718 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/49ec3e6dc27c0bf2917660a077788b8122510e7f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. T. Hirano
2. Guobin He
3. M. Karin
4. B. K. Pedersen
5. N. Perkins
6. S. Ghosh
7. M. Hayden
8. Bharat B. Aggarwal

In Immunology

1. B. K. Pedersen
2. M. Karin
3. T. Hirano
4. C. Fischer
5. S. Ghosh
6. N. Perkins
7. M. Hayden
8. S. Grivennikov

In Oncology

1. M. Karin
2. T. Hirano
3. B. K. Pedersen
4. Guobin He
5. N. Perkins
6. Bharat B. Aggarwal
7. S. Grivennikov

Citations in the corpus

• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “JAK kinase mediates the phosphorylation of tyrosine residues that are an integral part of the gp130,which in further stages results in the activation of STAT3, phosphorylation of MAPK, and activation of the PI3 K/AKT pathway [114, 115].”
• Role of myokines in exercise and metabolism. (2007, background): “The two IL-6 receptors, gp130 and IL-6R (also known as gp80 or CD126), belong to the type I cytokine receptor family, which, in addition to the above cytokines, comprises leptin, growth hormone, prolactin, erythropoietin, thrombopoietin, and granulocyte- and granulocyte/macrophage-colony stimulating”
• The role of IL-6 and STAT3 in inflammation and cancer. (2005, background): “Interleukin (IL)-6 is a potent, pleiotropic, inflammatory cytokine that mediates a plethora of physiological functions, including the developmental differentiation of lymphocytes, cell proliferation, and cell survival and amelioration of apoptotic signals [18–20].”
• Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? (2006, background): “IL-6 can also stimulate or inhibit its own synthesis.(16) IL-6 is a differentiation factor for B lymphocytes and an activator for T lymphocytes.”
• Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression (2010, background): “200 Cell 140, 197–208, January 22, 2010 ª2010 Elsevier Inc. Consistent with the increase in STAT3 activation, we found that obese mice exhibited elevated circulating IL-6 (Figure 4D), a potent STAT3-activating cytokine (Kamimura et al., 2003).”
• IL-6 in inflammation, autoimmunity and cancer (2020, background): “These multiple signal transduction pathways intimately regulate cell survival, proliferation, inflammation, immunity, angiogenesis, and tumor development and progression through the expression of several genes (1, 19, 21, 26, 31).”
• Inflammatory Cytokines in Experimental and Human Stroke (2012, background): “…allows the formation of gp130/gp130 homodimers that associates with Janusassociated kinases, activates signal transducer and activator of transcription and mitogen-activated protein kinase signaling pathways (Heinrich et al, 2003; Kamimura et al, 2003; Ernst and Jenkins, 2004; Bauer et al, 2007).”
• Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. (2008, background): “Our results demonstrate that the levels of activated STAT3, the primary STAT protein activated by ligation of the IL-6 receptor (Kamimura et al., 2003; Kishimoto, 2005), are significantly reduced in IL-6 -deficient myoblasts in vitro.”