The language of covalent histone modifications

By Brian D. Strahl, C. D. Allis. Nature, 2000

8,818 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/521776291aad4536a23a434611cd1d217e38435e

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Citations in the corpus

Post-translational modifications in signal integration (2010, background): “Acetylation of histones on conserved N-terminal tails has long been implicated in the activation of gene expression, owing to the weakening of the histone-DNA interaction and the alteration of histone-histone interaction”
Beyond GWASs: illuminating the dark road from association to function. (2013, background): “The accessibility of these factors is dependent on chromatin structural changes mediated by posttranslational histone modifications, such as methylation and acetylation.(43) Importantly, regulatory signals can act over long genomic distances and are brought into contact with target promoters via thr”
Ubiquitin and proteasomes: Protein regulation by monoubiquitin (2001, background): “In some cases, determinants from the substrate (including those resulting from other post-translational modifications such as phosphorylation and acetylatio”
NF-κB RelA Phosphorylation Regulates RelA Acetylation (2005, background): “These modifications, alone or in combination, create specific marks defining the actual or potential transcriptional state of the target genes (2, 15, 28).”
Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence (2002, background): “It has been proposed that these histone modi®cations constitute an epigenetic code, which can be interpreted in terms of chromatin structural changes leading to subsequent genome regulation (Strahl and Allis, 2000; Jenuwein and Allis, 2001).”
RNA meets chromatin. (2005, background): “Together, this variation may contribute to what has been referred to as a “histone code” (Turner 1993, 2000; Strahl and Allis 2000), which remains poorly understood.”
Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle. (2017, background): “The N-terminal histone “tails” are unstructured and protruded from the nucleosome [1], and are subject to extensive posttranslational modifications, or histone marks (reviewed in [2]), The potential functional role of histone marks was first postulated by Allfrey in 1964 [3] and subsequently develop”
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells (2001, background): “One of the most important mechanisms in chromatin remodeling is the post-translational modi®cation of the N-terminal tails of histones by acetylation, which apparently contributes to a `histone code' determining the activity of target genes (Strahl and Allis, 2000).”
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome (2007, background): “Significant progress in the fields of epigenetics and chromatin biology suggests a histone cod”
Histone methylation: a dynamic mark in health, disease and inheritance (2012, neutral): “KMT2A (MLL1, HRX, TRX1, ALL1) Histone H3 lysine 4 (H3K4) 11q23 AF4, ELL, AF9, ENL, AF6 and others t(X;11)(q13;q23) t(1;11)(p32;q23) t(1;11)(q21;q23) t(2;11)(p21;q23) t(4;11)(q21;q23) t(6;11)(q27;q23) t(9;11)(p22;q23) t(10;11)(p11–13;q23) t(11,11)(q23;q25) t(11;14)(q23;q32) t(11;17)(q23;q12) t(11;17)”
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. (2005, background): “The “histone code” hypothesis (Strahl and Allis 2000; Turner 2000; Jenuwein and Allis 2001) predicts that different modifications at specific amino acid residues in histones or combinations of these modifications are translated into functionally distinct nuclear processes.”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “Besides acetylation, other posttranslational modifications such as phosphorylation and methylation also do occur in core histone tails (465, 466, 469, 470, 475).”
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. (2003, background): “The posttranslational modification of core histones within chromatin, including acetylation, methylation, and phosphorylation, is involved in transcriptional regulation (Bradbury 1992; Strahl and Allis 2000).”