NF-κB RelA Phosphorylation Regulates RelA Acetylation

By Lin-Feng Chen, S. Williams, Y. Mu, H. Nakano, J. Duerr, Leonard Buckbinder, W. Greene. Molecular and Cellular Biology, 2005

402 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/29a3edcf960e05f95a6d554e6876ea73c5360356

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Citations in the corpus

Good cop, bad cop: the different faces of NF-κB (2006, background): “Recently, phosphorylation of RelA at Ser-276 and Ser-536 has been shown to promote acetylation at Lys310 and the assembly of RelA with coactivator p300.(57) RelA”
The Regulation of NF-κB Subunits by Phosphorylation (2016, background): “Phosphorylation at S536 in the transactivation domain (TAD) of p65 leads to enhanced transactivation, through increased CBP/p300 binding and acetylation at K310 of p65 [74].”
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300 (2006, background): “Although the current study and recently published work (17) help to address the significance of RelA/p65 S536 phosphorylation, there are still many unanswered questions about SMRT derepression from active NF- B transcriptional complex.”
Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, neutral): “It has been documented that both interaction of RelA with p300 and acetylation of RelA by p300 require phosphorylation of RelA (Chen et al., 2005).”
Signalling through C-type lectin receptors: shaping immune responses (2009, background): “The phosphorylation of the NF-κB subunit p65 at ser276 by RAF1 enables binding of the histone acetyltransferases CReB-binding protein (CBP) and p300 to p65, which leads to the acetylation of p65 on several lysine residues 3, 23 .”
NF-κB, the first quarter-century: remarkable progress and outstanding questions. (2012, background): “2005), although this result appears to be inconsistent (Chen et al. 2005).”
The NF-kappaB family of transcription factors and its regulation. (2009, background): “Numerous effects have been ascribed to this modification, including regulation of p65 nuclear localization and CBP/p300 interaction (Chen et al. 2005; Perkins 2006).”
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway (2006, background): “Indeed, a link between phosphorylation and acetylation has been demonstrated, with Ser-276 and Ser-536 phosphorylation resulting in increased p300 binding and therefore enhanced RelA acetylation at Lys-310 (Hoberg et al., 2004; Chen et al., 2005).”