Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
By M. Göttlicher, S. Minucci, P. Zhu, O. Krämer, A. Schimpf, Sabrina Giavara, J. Sleeman, F. Lo Coco, C. Nervi, Pier Giuseppe Pelicci and 1 more. EMBO Journal, 2001
1,898 citations recorded by the source corpus.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/09ccdb9c198818109347e9e0aa6828311cce4402
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In Molecular Biology
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Citations in the corpus
- Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “Interestingly, the antiepileptic valpromide (K/V), which is an amide analog of VPA but is not an HDAC inhibitor (Gottlicher et al., 2001), does not block the downregulation of GluR2 after KA treatment.”
- Multiple roles of HDAC inhibition in neurodegenerative conditions (2009, background): “Valproic acid, a fatty acid derivative with mood stabilizing and anticonvulsant properties, is another HDAC inhibitor that binds to the active site of the enzymes [12,13]; valproic acid inhibits Class I and Class IIa HDACs, but not Class IIb [14].”
- The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases,, (2015, background): “other 16 forms of the enzyme, which are involved in many additional functions (Göttlicher et al., 2001).”
- Histone-deacetylase inhibitors: novel drugs for the treatment of cancer (2002, background): “asp?DrugCode=1%2D1882&DrugName=VALPROIC+ACID+ORAL&DrugType=1">valproic acid , inhibit HDAC activity and affect the expression of numerous genes with disparate cellular function”