Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea

By A. Khoruts, J. Dicksved, Janet K. Jansson, M. Sadowsky. Journal of Clinical Gastroenterology, 2009

646 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/514c53461314399167de061c092f22410ee7a00a

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Citations in the corpus

Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. (2011, background): “Various reports have documented changes to the intestinal microbiota after IMT [44, 48, 61], and the microbiota of treated patients typically has been shown to resemble that of the donor after infusion [44, 61].”
Metagenomic biomarker discovery and explanation (2011, background): “Other important clinical applications of metagenomic analyses include probiotic treatments [94,95] and microbiome transplantation [96-99] for gastrointestinal diseases.”
Experimental and analytical tools for studying the human microbiome (2011, background): “Causality has been established in a few cases: stool transplantations from one human to another can cure persistent Clostridium difficile infection”
Factors affecting the composition of the gut microbiota, and its modulation (2019, background): “Regardless of the route of FMT, there is enough evidence supporting the conclusion that FMT is a highly efficient, and therapeutic option for several intestinal diseases, characterized by ability to restore the compositions and functions of gut microbiota which are similar to gut microbiota of recip”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “…who was infused with her husband’s microbiota through a colonoscope, there was a rapid and prolonged change in the bacterial composition of her gut microbiota, with Bacteroides spp. becoming dominant, C. difficile disappearing, and defecation frequency returning to normal (Khoruts et al. 2010).”
Defining the Human Microbiome (2012, background): “difficile infection is replaced by the donor community[67, 73].”
Shifting the balance: antibiotic effects on host–microbiota mutualism (2011, background): “New therapeutic approaches towards this aim include faecal bacteriotherapy from healthy donors following antibiotic treatment, and exogenous immune activation during the course of antibiotic therap”
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: ‘RePOOPulating’ the gut (2013, background): “Our study showed that the microbiota of both patients adapted characteristics of the stool substitute mixture yet still retained some of their original microbiota, similar to that described for stool transplants [20].”
Human genetics shape the gut microbiome. (2014, neutral): “Because the microbiome can be modified for therapeutic applications (Borody and Khoruts, 2012; Hamilton et al., 2013; Khoruts et al., 2010; van Nood et al., 2013), it constitutes an attractive target for manipulation.”
The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, neutral): “Khoruts et al. showed how transplanting the microbial community from a healthy donor to a patient suffering from Clostridium difficileassociated disease (CDAD) significantly modified the bacterial composition in the patient (Khoruts et al., 2010).”
Chapter 12: Human Microbiome Analysis (2012, background): “Within days, not only had she begun a complete recovery, but a metagenomic survey of her microbiota showed that the new community was almost completely established and had restored normal taxonomic abundances [162].”
Fecal microbiota transplantation and emerging applications (2012, background): “The prompt reconstitution of normal microbiota in FMT, even with a single infusion, is therefore so complete and durabl”