Defining the Human Microbiome

By L. Ursell, J. Metcalf, Laura Wegener Parfrey, Rob Knight. Nutrition reviews, 2012

1,068 citations recorded by the source corpus.

Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how we define the microbiome and its constituents. In this review we highlight recent research that expands our ability to understand the human microbiome on different spatial and temporal scales, including daily timeseries datasets spanning months. Furthermore, we discuss emerging concepts related to defining operational taxonomic units, diversity indices, core versus transient microbiomes and the possibility of enterotypes. Additional advances in sequencing technology and in our understanding of the microbiome will provide exciting prospects for exploiting the microbiota for personalized medicine.

Subfields: Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1f02a025bb280593e0a106a32ec1da9d4b1e4f19

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In Molecular Biology

Citations in the corpus

Next-Generation Sequencing — An Overview of the History, Tools, and “Omic” Applications (2016, background): “[177] Ursell LK, Metcalf JL, Parfrey LW, Knight R: Defining the human microbiome.”
The Gut Microbiota and Inflammation: An Overview (2020, background): “The genetic and functional profile of microbial species is termed the gut microbiome [3].”
The rhizosphere microbiome: significance of plant beneficial, plant pathogenic, and human pathogenic microorganisms. (2013, background): “Analogous to the concept of the core microbiome in human microbiology (Turnbaugh et al., 2009; Huse et al., 2012; Ursell et al., 2012), we define the core rhizosphere microbiome in the context of plant health as the set of microorganisms that are needed to effectively protect plants from soilborne…”
The amphibian microbiome: natural range of variation, pathogenic dysbiosis, and role in conservation (2017, background): “Sources Faith (1992), Moreira and López-Garcı́a (2011), Lozupone et al. (2011), Kuczynski et al. (2011), Morgan and Huttenhower (2012), Ursell et al. (2012), Swenson (2014a, b) Alpha diversity within-sample taxonomic diversity, acts as a summary statistic of a single population Beta diversity…”
Metabarcoding: A powerful tool to investigate microbial communities and shape future plant protection strategies (2017, background): “Microbiome refers to the study of the entirety of the microbial genetic material recovered directly from the environment, also known as shotgun metagenomics, while microbiota refers to the taxonomic composition of the microbial community as determined by metabarcoding analysis (Ursell et al., 2012).”