Human genetics shape the gut microbiome.

By Julia Goodrich, Jillian L. Waters, Angela C. Poole, Jessica L. Sutter, Omry Koren, R. Blekhman, M. Beaumont, William W. Van Treuren, Rob Knight, Jordana T. Bell and 3 more. Cell, 2014

2,776 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/5d02adc756510c2d0d0f10820dbc988c216572dd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Rob Knight
2. Ruth E. Ley
3. J. Lennon
4. Susan P. Holmes
5. Dirk Gevers
6. Paul J. McMurdie
7. E. Costello
8. David A. Relman

In Physiology

1. Rob Knight
2. Dirk Gevers
3. Eran Elinav
4. J. Lennon
5. Ruth E. Ley
6. Julia Goodrich
7. David A. Relman
8. J. Rawls

In Public Health, Environmental and Occupational Health

1. Rob Knight
2. Eran Segal
3. Ruth E. Ley
4. David A. Relman

Citations in the corpus

• A practical guide to methods controlling false discoveries in computational biology (2018, background): “840333 [70]: (1) obesity [71], (2) inflammatory bowel disease (IBD) [72], (3) infectious diarrhea (clostridium difficile (CDI) and non-CDI) [73], and (4) colorectal cancer (CRC) [74].”
• Genetic determinants of the gut microbiome in UK Twins (2016, positive): “Fecal samples were collected as described previously (Goodrich et al., 2014; Jackson et al., 2015).”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “Administration of Christensenella minuta was reported to alter the microbial ecology and protect mice from obesity.(165) In a recent study, administration of Lactobacillus reuteri was reported to increase insulin secretion by promoting incretin release in obese glucose-tolerant subjects.”
• Host genetic variation impacts microbiome composition across human body sites (2015, methodology): “identified microbial taxa for which relative abundance is more similar in monozygotic compared to dizygotic twins [14].”
• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Christensenella minuta Reduces weight gain in mice inoculated with obese human fecal samples (Goodrich et al., 2014)”
• Integrative omics for health and disease (2018, background): “Recently, human genetic profiles have been shown to influence overall gut microbiota composition 116,117 , which could suggest putative causal explanations for some disease-associated genetic loci 118 (for recent reviews, see REFS 119,120 ).”
• Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling (2015, background): “A dysbiotic state can be established in multiple ways, including intestinal infection (Lupp et al., 2007; Stecher et al., 2007) auto-inflammation (Devkota et al., 2012), altered host genetics (Goodrich et al., 2014), and dietary modulation (David et al., 2014).”