Understanding the mechanism of IL-1β secretion
By G. López‐Castejón, D. Brough. Cytokine & growth factor reviews, 2011
1,403 citations recorded by the source corpus.
The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury. It is not surprising therefore that there is a huge level of interest in how this protein is produced and exported from cells. However, the mechanism of IL-1β release has proven to be elusive. It does not follow the conventional ER-Golgi route of secretion. A literature full of disparate observations arising from numerous experimental systems, has contributed to a complicated mix of diverse proposals. Here we summarise these observations and propose that secretion of IL-1β occurs on a continuum, dependent upon stimulus strength and the extracellular IL-1β requirement.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/a8a52794257dfd46ed130a481d468b3fccc635d2
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In Immunology
In Molecular Biology
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Citations in the corpus
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “As noted earlier, succinate (via HIF-1 ) upregulates the expression of IL-1 , a cytokine that is an important mediator of the inflammatory response (289).”
- The P2X7 Receptor in Infection and Inflammation (2017, positive): “Several alternative mechanisms have been suggested, such as passive release following cell death and secretion via modified lysosomes, exosomes, or plasma membrane-derived microvesicles (MacKenzie et al., 2001; Lopez-Castejon and Brough, 2011; Piccioli and Rubartelli, 2013).”