Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

By Chunming Liu, Yiming Li, Mikhail V. Semenov, Chun Han, G. Baeg, Yi Tan, Zhuohua Zhang, Xinhua Lin, Xi He. Cell, 2002

1,057 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/50bdf6649cd933d65f001a3fe0afcdcfa9fa5860

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Citations in the corpus

Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled (2004, methodology): “The kinase assays were initiated by the addition of 2 g of GST-Jun(1-109)”
β-Catenin signaling is required for neural differentiation of embryonic stem cells (2004, background): “Initially, β-catenin is phosphorylated on Ser45 by a ‘priming’ kinase (Liu et al., 2002).”
Nucleo-cytoplasmic distribution of β-catenin is regulated by retention (2006, background): “In unstimulated cells, catenin is targeted for ubiquitination and subsequent degradation by phosphorylation by glycogen synthase kinase 3 and casein kinase 1 (Liu et al., 2002; Rubinfeld et al., 1996) in a multiprotein complex where it is bound by the scaffold proteins axin or axin2/conductin (Behre”
Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “…receptors are not engaged by ligands, CK1 and GSK3 sequentially phosphorylate Axin-bound b-catenin at a series of regularly spaced N-terminal Ser/Thr moieties: b-catenin is first phosphorylated by CK1 at Ser45, followed by GSK3 phosphorylation at Thr41, Ser37, and Ser33 residues (Liu et al., 2002).”
Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines (2007, methodology): “C IH R A uthor M anuscript C IH R A uthor M anuscript C IH R A uthor M anuscript Validation of β–catenin as a GSK-3 Target Phosphorylation of β-catenin by GSK-3 on residues 33, 37 and 41 has been well documented (Amit et al., 2002; Hagen et al., 2002; Liu et al., 2002; Salic et al., 2000).”
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling (2005, background): “Finally, NTAIL has little predicted secondary structure (Bourhis et al., 2004), a feature that has been recently noticed in protein regions with no ordered regular structure (Liu et al., 2002b).”
GSK-3: tricks of the trade for a multi-tasking kinase (2003, background): “Five groups have recently determined that β-catenin is also a primed substrate for GSK-3, with casein kinase I (CKI) acting as the priming kinase (Amit et al., 2002; Hagen et al., 2002; Hagen and Vidal-Puig, 2002; Liu et al., 2002; Sakanaka, 2002; Yanagawa et al., 2002).”
The many faces and functions of β‐catenin (2012, unknown): “CK1 a phosphorylates b -catenin at Ser45, priming the sequential phosphorylation of Thr41, Ser37, and Ser33 by GSK3 (preferentially by GSK3 b ) (Liu et al , 2002; Xing et al , 2003).”
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer (2023, background): “tion, enhancing its transcriptional activity [139], resulting”
Phospho-regulation of β-Catenin Adhesion and Signaling Functions (2007, background): “CK1α phosphorylates β-catenin at serine 45, and this priming phosphorylation results in subsequent phosphorylation by GSK3β at residues 41, 37, and 33 (49,88) (FIGURE 2B).”