GSK-3: tricks of the trade for a multi-tasking kinase

By B. Doble, J. Woodgett. Journal of Cell Science, 2003

2,180 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7ee8f1753ec894642235373ba64c8709db7b2485

How researchers see this paper

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In Molecular Biology

1. T. Force
2. A. D. Kohn
3. B. Doble
4. J. Woodgett
5. J. Isaac
6. G. Collingridge
7. R. Moon
8. Christof Niehrs

Citations in the corpus

• Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity (2016, neutral): “It was later shown to be a key component of the Wnt signalling pathway, which plays important roles in embryonic development and tumorigenesis 17,18 .”
• Serotonin modulates circadian entrainment in Drosophila. (2005, background): “GSK3β activity is regulated (inhibited) by phosphorylation of an N-terminal pseudosubstrate site (ser9) and thus can be monitored through the use of phosphospecific antibodies directed to this modified form (Doble and Woodgett, 2003; Papadopoulou et al., 2004).”
• The activation of Akt/PKB signaling pathway and cell survival (2005, background): “GSK3 is also involved in many other signaling pathways, including the β-catenin-TCF/LEF transcriptional pathway [98].”
• Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines (2007, background): “However, it has since been shown to play far broader roles in many cellular processes (Doble and Woodgett, 2003).”
• Protein kinase cascades in the regulation of cardiac hypertrophy. (2005, background): “both of these branches can also be regulated by stress-activated, Gq-dependent mechanisms that are independent of Akt (Figure 1) (32, 33), which likely explains in part the ability of the Akt1–/– mouse heart to hypertrophy in response to pathologic stress.”
• LTP inhibits LTD in the hippocampus via regulation of GSK3beta. (2007, positive): “Other upstream signalling pathways can also regulate GSK3β and, in the case of Wnt signalling, this involves direct protein:protein interactions with GBP/FRAT1 (Doble and Woodgett, 2003).”
• WNT and β-catenin signalling: diseases and therapies (2004, background): “GSK3, as its name (glycogen synthase kinase) implies, is regulated by other pathway”
• Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination. (2016, background): “Plasma contains many types of enzymes (such as glycogen synthase) [17] that enable the breakdown and metabolism of various biomolecules (such as cholesterol, and bilirubin) in bile ducts.”