Obesity and Free Fatty Acids (FFA)
By G. Boden. Endocrinology and metabolism clinics of North America (Print), 2008
844 citations recorded by the source corpus.
Plasma free fatty acid (FFA) levels are elevated in obesity. FFAs cause insulin resistance in all major insulin target organs (skeletal muscle, liver, endothelial cells) and have emerged as a major link between obesity, the development of the metabolic syndrome, and atherosclerotic vascular disease. FFAs also produce low-grade inflammation in skeletal muscle, liver, and fat, which may contribute to cardiovascular events. The challenges for the future include the prevention or correction of obesity and elevated plasma FFA levels through methods that include decreased caloric intake and increased caloric expenditure, the development of methods to measure FFAs in small blood samples, and the development of efficient pharmacologic approaches to normalize increased plasma FFA levels.
Subfields: Molecular Biology, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/01b64f7a169356dbd76d7e463b2d1ae26a945ba6
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Citations in the corpus
- Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009, background): “However, our data are not able to determine whether this association is a cause-and-effect relationship, and other mechanisms for insulin resistance have also been proposed (13, 14).”
- Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “acids into the circulation from adipocytes, which may be a critical factor in modulating insulin sensitivity [11,12].”