Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion.

By B. Dirat, L. Bochet, M. Dabek, Danièle Daviaud, S. Dauvillier, B. Majed, Y. Wang, Aline Meulle, B. Salles, S. Le Gonidec and 4 more. Cancer Research, 2011

996 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/910c2ab44f1b5219de86837bde16fef5ad50a83c

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Citations in the corpus

Obesity and adverse breast cancer risk and outcome: mechanistic insights and strategies for intervention (2017, background): “Notably, IL-6 levels in peritumoral fat are higher than in all other breast quadrants(106) and increase with increasing tumor size and lymph node involvement.(10) Recent work has shown that contact between breast cancer”
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “of adipocytes into adipocyte-derived fibroblasts (ADFs), which express one CAF marker, FSP-1, at high levels [61, 62].”
Adipose tissue and adipocytes supports tumorigenesis and metastasis (2013, background): “Several reports suggest that in the presence of cancer cells, adipocytes revert from mature, differentiated adipocytes to preadipocytes by delipidation, a process by which adipocytes secrete their lipids [56,57].”
Tumor-associated stromal cells as key contributors to the tumor microenvironment (2016, background): “[22] showed that mature adipocytes co-cultured with breast cancer cells increase their expression of matrix metalloproteinases (MMP-11) as well as the pro-inflammatory cytokines interleukin (IL)-6 and IL-1β.”
Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “content and release of adipokines and secreting tumor-promoting substances such as matrix metalloproteinases [117].”
Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “In addition, both activated adipocytes and activated fibroblasts can express spectrums of ''proinflammatory'' mediators (Celis et al., 2005; Dirat et al., 2011; Erez et al., 2010), thereby recruiting and activating IICs that, in turn, provide mitogenic signals to cancer cells, as well as other cell…”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “For example, breast cancer invasiveness can be stimulated through the secretion of interleukin-6 (IL-6) by adipocytes present in the local microenvironment (Dirat et al., 2011).”