Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

By E. Daugas, S. Susin, N. Zamzami, K. Ferri, T. Irinopoulou, N. Larochette, M. Prevost, B. Leber, David W. Andrews, Josef M. Penninger and 1 more. The FASEB Journal, 2000

815 citations recorded by the source corpus.

Subfields: Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4fa76b7b31683c8af29ca7eaa09e3dd22094984c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Guido Kroemer
2. M. Jäättelä
3. T. Mak
4. K. Ferri
5. Marcel Leist
6. Josef M. Penninger
7. L. Galluzzi
8. Simone Fulda

In Nutrition and Dietetics

1. Guido Kroemer

Citations in the corpus

• NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “AIF is a NADH oxidase, which appears to be both an important pro-death factor and an important pro-survival factor (76, 174, 202).”
• Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death (2001, background): “We previously cloned apoptosis-inducing factor (AIF), which, like cytochrome c , is normally present in the mitochondrial intermembrane space and is released in response to death stimul”
• Four deaths and a funeral: from caspases to alternative mechanisms (2001, background): “Defects in any step of the cytochrome c or AIF pathways will result in a switch from apoptosis to cell death with a necrotic morpholog”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Nuclear localization of AIF leads to induction of chromatin condensation, DNA fragmentation and finally caspase-independent apoptosis (Daugas et al., 2000).”